Results 81 to 90 of about 201,967 (310)

Assessment of the genotoxicity of Cu and Zn in raw and anaerobically digested slurry with the Vicia faba micronucleus test [PDF]

, 2009
Genotoxicity of Cu and Zn was assessed by use of the micronucleus (MN) test on Vicia faba roots. Plants were exposed to various leachates of rawand anaerobically digested pig slurry, with maximum total concentrations of 200MCu and 600MZn.
Marcato, Claire-Emmanuelle, Silvestre, Jérôme, Pinelli, Eric, Pourrut, Bertrand, Guiresse, Agnès Maritchù, Guiresse, Maritxu   +5 more
core   +1 more source

Silicon Mitigates the Effects of Potentially Toxic Metals

, 2023
Heavy metals deliberately released into the environment can cause serious environmental damage, as they tend to accumulate in cultivated soils, affecting crops, which start to absorb them through their roots, and when absorbed in high amounts they can ...
da Silva, Dalila Lopes, de Oliveira, Lilian Aparecida, Rodrigues Cruz, Flávio José, de Mello Prado, Renato [UNESP], Abreu-Junior, Cassio Hamilton   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Use of Isihlambezo in the Upper Tugela Region

South African Family Practice, 1991
No abstract available.
Gary Morris, B.E. Mdlalose
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Acute spontaneous and experimental poisoning by Solanum pseudoquina in cattle [PDF]

Pesquisa Veterinária Brasileira
: The epidemiology, toxic potential, and clinical and pathological presentation of acute spontaneous and experimental poisoning by Solanum pseudoquina are described.
Elaine Melchioretto, Daiane Ogliari, Tainara R. Tineli, Franciéli A. Molossi, Aldo Gava   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Identification of toxic plants and their effect on livestock and other animals of Boyacá and Cundinamarca

Temas Agrarios
Research on toxic plants must be communicated on a larger scale as much as possible to associations and communities of livestock farmers that promote the existence of this economic sector.
Manuel Galvis Rueda, Manuel Torres Torres   +1 more
doaj   +1 more source

Annona muricata (graviola): toxic or therapeutic

, 2008
This paper examines annona muricata (graviola): toxic or ...
Hollinshead, J., Watson, A.A., Jones, L., Mohanty, S., Jones, P.W., Gray, A.I., Thomas, D., Watson, D.G.   +7 more
core