Results 81 to 90 of about 2,178,903 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Toxic Substances Control Act, The

, 1984
Title from PDF cover (viewed on Feb. 3, 2010).; "July 1984."; "EPA 560/1-83-002.

core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Review on the Toxicity and Safety of Medicinal Plants during Pregnancy

Proceedings
Introduction: Although herbs are widely used and considered safe, they can be toxic, especially during pregnancy [...]
Aniket Rajesing Girase, Javesh Kashinath Patil, Devshree Yashwantbhai Patel, Harsha Vasudev Chaudhari, Sachinkumar Madhukar Mahajan   +4 more
doaj   +1 more source

Plants 2022 Best Paper Award

, 2022
Plants is instituting the Best Paper Awards to recognize the outstanding papers published in the journal [...
Plants Editorial Office Plants Editorial Office
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Plants 2021 Best Paper Award

, 2021
Plants is instituting the Best Paper Awards to recognize the outstanding papers published in the journal [...
Plants Editorial Office Plants Editorial Office
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Plants Toxic to Farm and Companion Animals

, 2017
Toxic plants are responsible for many cases of poisoning of farm and companion animals throughout the world. Livestock and horses may be poisoned when these plants contaminate hay or silage or alternative forages are unavailable.
C. Cortinovis, F. Caloni, Cristina Cortinovis, Francesca Caloni   +3 more
core   +1 more source