Results 171 to 180 of about 283,312 (250)

pKa engineering of a near‐infrared fluorescent probe for sensitive imaging of oxidative stress in atherosclerotic plaques

Smart Molecules, EarlyView.
A pKa‐engineered near‐infrared fluorescent probe (DCM‐2F‐B) enables sensitive imaging of oxidative stress in atherosclerotic plaques. Difluoro substitution lowers the phenolic hydroxyl pKa from 9.1 to 6.0, achieving near‐complete ionization at physiological pH.
Qianqian Yu, Jiahui Liang, Tijian Zhou, Qiaomeng Chen, Xuechun Yan, Zhikang Zheng, Huyou Wang, Jihong Liu, Yi Dong, Wei‐Hong Zhu, Qi Wang   +10 more
wiley   +1 more source

Associations of Cholesin and GPR146 with atherosclerotic plaque stability: integrated bioinformatics and functional analyses. [PDF]

Front Cardiovasc Med
Liu Q, Geng Y, Wang Y, Lv T, Zhang P.
europepmc   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

CD8⁺ effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging. [PDF]

Immun Ageing
Weyh C, Größer V, Minuzzi LG, Frech T, Gebhardt K, Nolte S, Dombrowski TR, Böttrich T, Hoffmann MA, Sommer N, Ringseis R, Eder K, Sossalla S, Bauer P, Krüger K.   +14 more
europepmc   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis. [PDF]

Biomolecules
Kulkarni AJ, Rai V.
europepmc   +1 more source

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source

Effects of different statin-based lipid-lowering therapies on stabilization and regression of carotid plaque: a randomized open-label trial. [PDF]

Front Pharmacol
Luo S, Lin L, Lin Y, Qiu P, Cai K, Huang H, Zeng Y, Huang H, Liang H, Xu Y.   +9 more
europepmc   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Correlation Between Serum TGF-β1 Levels, Intracranial Atherosclerotic Plaque Parameters and Post-Stroke Cognitive Impairment. [PDF]

Int J Gen Med
Zhang YG, Yang PF, Liu BJ, Wang S, Li KY, Zhong H, Jiang YR, Yuan B.   +7 more
europepmc   +1 more source