Results 181 to 190 of about 503,732 (331)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

CYP2C19 Loss‐of‐Function Is an Independent Risk Factor of Coronary Artery Disease in Patients With Hypertension

Journal of Clinical Laboratory Analysis, EarlyView.
The relationship between Cytochrome P450 2C19 (CYP2C19) polymorphisms and coronary artery disease (CAD) in hypertensive patients was analyzed. CYP2C19 loss‐of‐function, BMI ≥ 24.0 kg/m2, and history of alcoholism were independent risk factors for CAD in hypertensive patients.
Guoliang Wei, Bin Li, Hao Wang, Wenhao Chen, Kehui Chen, Weihong Wang, Shen Wang, Hui Zeng, Yuanliang Liu, Yue Zeng, Hui Rao   +10 more
wiley   +1 more source

Study of Risk Factors and Image Findings of Isolated Abdominal Incidentally Detected Aortic Dissection

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 429-435, March/April 2025.
We detect the risk factors and image characteristics of incidentally detected IAAD. Independent risk factors of IAAD included fatty liver and smoking. In the ultrasound findings of IAAD, an intimal flap was frequently observed. In the CT scan, displacement of intimal calcifications was frequently observed. For suspected IAAD, the abdominal aorta should
Hiromasa Tsubouchi, Hidenori Onishi, Koji Maeno, Masaya Nakagaichi, Ikue Tsukushi, Youichi Kitano, Yoshitaka Makino, Hiroyuki Hayashi, Hidekazu Terasawa, Hiroko Kabuto, Toshihiro Misawa, Taku Sanada, Azusa Hisada, Kazuo Notsumata, Kazuhiro Okafuji, Osamu Yamamura   +15 more
wiley   +1 more source

The Development and Challenges of PET/MRI Dual‐Modality Imaging Probes—An Update

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high‐resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image‐guided therapies. Central to the success of this dual‐modality system is the
Maryam Sabbaghan, Saumya Nigam, Isabella Kasabasic, Medha Manepalli, Ping Wang, Jinda Fan   +5 more
wiley   +1 more source

The Diagnostic Value of Contrast‐Enhanced Vessel Wall MRI for Diagnosing Neuropsychiatric Systemic Lupus Erythematosus

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Imaging biomarkers for neuropsychiatric systemic lupus erythematosus (NPSLE) are highly needed, and intracranial contrast‐enhanced vessel wall imaging (CE‐VWI) can potentially detect cerebral vessel wall abnormalities in lupus. Purpose To evaluate the diagnostic value of CE‐VWI in differentiating NPSLE from non‐NPSLE.
Satoru Ide, Yuya Fujita, Yu Murakami, Koichiro Futatsuya, Yuta Yoshimatsu, Jun Tsukamoto, Haruka Oku, Toshihiro Sakamoto, Yoshiya Tanaka, Takatoshi Aoki   +9 more
wiley   +1 more source

Murine Supraspinatus Tendons Demonstrate Aging‐Related Changes in Multiscale Mechanics, Structure, and Gene Expression

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Rotator cuff disorders are common in the aging population, often leading to pain, disability, and reduced quality of life. Age‐associated changes can occur disproportionately in regions of high mechanical stress, such as the insertion site of the supraspinatus tendon, leading to increased injury rates and tendinopathies.
Michael S. DiStefano, Jeremy D. Eekhoff, Stephanie N. Weiss, Courtney A. Nuss, Rebecca L. Betts, Andrew F. Kuntz, Louis J. Soslowsky   +6 more
wiley   +1 more source

Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study

Journal of Periodontology, EarlyView.
Abstract Background The relationship between periodontitis and erectile dysfunction (ED) has been poorly documented in Caucasian populations, particularly severe ED (SED) requiring penile prostheses. This study aimed to evaluate the association between periodontitis and SED in patients undergoing penile prosthesis implantation, and to identify clinical
Miguel Ángel Arrabal‐Polo, Ana López‐Toruño, Antonio Magan‐Fernández, Miguel Arrabal Martin, Natividad Martín‐Morales, Eva Rosel, Manuel Bravo, Francisco O´Valle, Francisco Mesa   +8 more
wiley   +1 more source

Association between periodontitis severity and prostate‐specific antigen levels using the NHANES data

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been linked to various systemic health conditions. This study investigated whether the association between periodontitis and prostate‐specific antigen (PSA) is direct or mediated through intermediary systemic diseases.
Muhammad H. A. Saleh, Khushboo Kalani, Hamoun Sabri, Shahad Alhazmi, Deepthy Nair, Todd M. Morgan, Hom‐Lay Wang, Ann M. Decker   +7 more
wiley   +1 more source

Imaging Characteristics of Persistent Carotid‐Vertebrobasilar Anastomoses Detected by Ultrasound

Journal of Ultrasound in Medicine, EarlyView.
In this case series, we aimed to evaluate the ultrasonic characteristics of 35 patients with persistent carotid‐vertebrobasilar anastomoses (PCVBA), a rare variant between the anterior and posterior cerebral circulation. Ultrasound detected seven (30.4%, 7/23) primitive trigeminal arteries (PTA), eight (100%, 8/8) primitive hypoglossal arteries (PHA ...
Xiang Li, Qiuping Li, Liyong Du, Yumeng Luo, Jie Yang, Tieying Zhang, Jiabin Liu   +6 more
wiley   +1 more source