Results 221 to 230 of about 143,458 (285)

Exonic Variation in HLA‐C, CFB, and TAP2 Associated With Increased Risk for Comorbid Crohn's Disease and Psoriasis

open access: yesInternational Journal of Dermatology, EarlyView.
Our recent work established an association between high polygenic risk scores (PRSes) for both psoriasis and Crohn's disease with the development of comorbid disease. The protein‐coding genetic variation associated with the development of comorbid psoriasis and Crohn's disease is understudied.
Vikram R. Shaw   +6 more
wiley   +1 more source

Progression of Established Atherosclerotic Lesions Is Not Inhibited by Endothelial Knockout of Caveolin-1-Brief Report. [PDF]

open access: yesArterioscler Thromb Vasc Biol
Muñiz-Anquela R   +8 more
europepmc   +1 more source

The causal effects of hypothyroidism on cardiovascular disease: Bidirectional and multivariable Mendelian randomization study

open access: yesJournal of Diabetes Investigation, EarlyView.
Our study suggests bidirectional causal associations between hypothyroidism and both coronary artery disease (CAD) and myocardial infarction (MI). Moreover, hypothyroidism contributes to an increased risk of peripheral atherosclerosis (PAS). ABSTRACT Background Whether hypothyroidism and cardiovascular disease (CVD) are causally related remains ...
Xuan Bai, Mengyi Sun, Xu Han
wiley   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault   +51 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

open access: yesJournal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron   +3 more
wiley   +1 more source

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