Results 211 to 220 of about 98,121 (309)

The Correlation between Inflammatory Markers and Carotid Atherosclerotic Plaque Characteristics. [PDF]

Cerebrovasc Dis Extra
Wang L, Chen T, Yuan C, Hatsukami T, Zhao X, Shen M, Gao P, Sun S, Zhao X, Sui B.   +9 more
europepmc   +1 more source

Gelatinase and Vulnerability of Atherosclerotic Plaque

Journal of Atherosclerosis and Thrombosis, 2016
openaire   +3 more sources

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Celastrol ameliorates atherosclerosis by inhibiting TLR4/STAT3/NLRP3-mediated macrophage pyroptosis. [PDF]

Chin Med
Shi Y, Li Z, Liu Q, Qiu Y, Long J, Yang Q, Zhang C, Gong Y, Qin L.   +8 more
europepmc   +1 more source

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, EarlyView.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Diagnostic Performance of General Practitioners in Carotid Plaque Detection Using AI-Enhanced Point-of-Care Ultrasound After Systematic Training. [PDF]

Ann Fam Med
Liu X, Yao S, Yang H, Pan Z.
europepmc   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Atherosclerotic plaque distribution and characteristics in young patients with stroke/transient ischemic attack: insights from MR vessel wall imaging and comparison with older counterparts. [PDF]

Quant Imaging Med Surg
He WW, Li T, Wang Y, Yang X, Mao YF, Wu FY, Shi HB, Su CQ, Lu SS.   +8 more
europepmc   +1 more source