Results 41 to 50 of about 283,312 (250)

Investigation for atherosclerotic plaque rupture with thrombosis in mice based on single-cell sequencing and bioinformatics analysis

Frontiers in Cardiovascular Medicine
IntroductionAtherosclerotic plaque rupture with thrombus formation leads to severe cardiovascular events. We hoped to explore the hub genes providing critical roles in the process of atherosclerotic plaque rupture accompanied by thrombus formation, which
Peng Nie, Fang Wan, Tianbao Yao, Yao Li, Guofeng Yan, Jun Pu, Shuxuan Jin   +6 more
doaj   +1 more source

Molecular analysis shows the presence of periodontal bacterial DNA in atherosclerotic plaques from patients with coronary artery disease

Indian Heart Journal, 2021
Links between periodontitis and atherosclerosis can be predicted based on inflammatory mechanisms initiated by bacteria associated with periodontal lesions, which then influence the initiation or propagation of the atherosclerotic lesion.
Amita Rao, Caroline D’Souza, K. Subramanyam, Praveen Rai, Biju Thomas, Mundayat Gopalakrishnan, Indrani Karunasagar, Ballamoole Krishna Kumar   +7 more
doaj   +1 more source

Modern Management of Asymptomatic Carotid Stenosis: A Meta‐Analysis of CREST‐2, SPACE‐2, and ECST‐2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Recent randomized trials (CREST‐2, SPACE‐2, and ECST‐2) have compared carotid revascularization (carotid endarterectomy [CEA] or carotid artery stenting [CAS]) plus contemporary medical therapy (CMT) versus CMT alone in asymptomatic carotid stenosis.
Aasim Ali, Waqar Ahmed Cheema, Fiza Nisar, Muhammad Shamoon, Sameen Sarfaraz, Ahmad Butt, Muhammad Abdullah Ali, Armaghana Abdullah, Muhammad Asad Shabbir, Muhammad Talha, Hammad Azam, Aimen Anwaar Pannun, Usama Saleem, Anousha Tanveer, Mukesh Sharma   +14 more
wiley   +1 more source

Numerical investigation of atherosclerotic plaque rupture using optical coherence tomography imaging and XFEM [PDF]

, 2018
Myocardial infarction contributes to most fatalities in which atherosclerotic plaque disruption is the underlying pathology. From the mechanics view point, the pulsatile blood flow in the arteries resembles a fatigue environment and generates stresses ...
Yarlagadda, Prasad K.D.V., Wang, Jiaqiu, Gu, YuanTong, Paritala, Phani Kumari, Li, Zhiyong   +4 more
core   +1 more source

The Complex Mechanisms and the Potential Effects of Statins on Vascular Calcification: A Narrative Review

Reviews in Cardiovascular Medicine
Vascular calcification (VC) is a complex process of calcium deposition on the arterial wall and atherosclerotic plaques and involves interaction between vascular smooth muscle cells, inflammatory and VC mediators. The latter are independent predictors of
Nikolaos PE Kadoglou, Marianna Stasinopoulou, Nikolaos Velidakis, Elina Khattab, Eirini Christodoulou, Evangelia Gkougkoudi, Georgia Valsami   +6 more
doaj   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Cellular and molecular components of the atherosclerotic process: Primary colture and characterization of human vascular smooth muscle cells from carotid artery [PDF]

, 2009
Introduction The last years were characterized by several studies proceeding to understand SMC heterogeneity. Animal models of rat or rabbit IT after endothelial lesion are presently the most studied models for atherosclerotic plaque formation and ...
Gagliano, Teresa
core  

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]

PLoS ONE, 2013
The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert, Wendy A Boivin, Hongyan Zhao, Bruce M McManus, David J Granville   +4 more
doaj   +1 more source

oxLDL downregulates the dendritic cell homing factors CCR7 and CCL21 [PDF]

, 2012
Dendritic cells (DCs) and oxLDL play an important role in the atherosclerotic process with DCs accumulating in the plaques during plaque progression.
Korbinian Lackermair, Kopp, Reinhard, Beiras-Fernandez, Andres, Kaczmarek, Ingo, Summo, Claudia, Andres Beiras-Fernandez, Weis, Michael, Robert David, Michael Weis, Marius Lambert, Thomas Nickel, Ingo Kaczmarek, Claudia Summo, Sicic, Zeljka, Georgios Meimarakis, Lackermair, Korbinian, Lambert, Marius, Nickel, Thomas, Susanne Pfeiler, Pfeiler, Susanne, Meimarakis, Georgios, Reinhard Kopp, Lackermair, Korbinian Johannes, Beiras Fernández, Andrés, Zeljka Sicic, David, Robert   +25 more
core   +1 more source