Results 21 to 30 of about 82,317 (266)

Stabilization of atherosclerotic plaques: an update [PDF]

European Heart Journal, 2013
The majority of coronary thrombi (∼75%) is caused by plaque rupture .1,2 Prototype of the rupture-prone plaque contains a large, soft, lipid-rich necrotic core with a thin and inflamed fibrous cap, so-called thin-cap fibroatheroma (TCFA) ( Figure 1 ).3,4 Other common features include expansive remodelling, large plaque size, plaque haemorrhage ...
Yla-Herttuala, S., Bentzon, J.F., Daemen, M., Falk, E., Garcia-Garcia, H.M., Herrmann, J., Hoefer, I., Jauhiainen, S., Jukema, J.W., Krams, R., Kwak, B.R., Marx, N., Naruszewicz, M., Newby, A., Pasterkamp, G., Serruys, P.W.J.C., Waltenberger, J., Weber, C., Tokgozoglu, L., ESC Working Grp Atherosclerosis Va   +19 more
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High-Resolution MRI of Intracranial Atherosclerotic Disease [PDF]

Neurointervention, 2014
Intracranial atherosclerotic disease (ICAD) causes up to 10% of all ischemic strokes, and the rate of recurrent vascular ischemic events is very high. Important predictors of vulnerability in atherosclerotic plaques include the degree of stenosis and the
Chang-Woo Ryu, Hyo-Sung Kwak, Geon-Ho Jahng, Han Na Lee   +3 more
doaj   +1 more source

Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

BMC Cardiovascular Disorders, 2012
Background This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a ...
Wong Kelvin KL, Thavornpattanapong Pongpat, Cheung Sherman CP, Sun Zhonghua, Tu Jiyuan   +4 more
doaj   +1 more source

Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging.

PLoS ONE, 2023
Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro.
Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhang   +6 more
doaj   +2 more sources

Vulnerable Atherosclerotic Plaque [PDF]

Circulation, 2003
The recent proliferation of invasive and noninvasive techniques to locate vulnerable atherosclerotic plaques raises important questions. Will such techniques add useful prognostic information? If so, will the information prevent myocardial infarction, stroke, or death in at least some patients at risk? Will it lead to new research advances?
Ward, Casscells, Morteza, Naghavi, James T, Willerson   +2 more
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Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice

Molecular Metabolism, 2021
Objective: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize ...
Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Härdtner   +17 more
doaj   +1 more source

Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Journal of Cardiovascular Development and Disease, 2019
Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early
Anouar Hafiane
doaj   +1 more source

Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients

Scientific Reports, 2023
Extracellular vesicles (EV) are a novel biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provide insight ...
Maarten C. Verwer, Joost Mekke, Nathalie Timmerman, Farahnaz Waissi, Arjan Boltjes, Gerard Pasterkamp, Gert J. de Borst, Dominique P. V. de Kleijn   +7 more
doaj   +1 more source

Regulation of atherosclerotic plaque inflammation [PDF]

Journal of Internal Medicine, 2015
AbstractThe immune reactions that regulate atherosclerotic plaque inflammation involve chemokines, lipid mediators and costimulatory molecules. Chemokines are a family of chemotactic cytokines that mediate immune cell recruitment and control cell homeostasis and activation of different immune cell types and subsets.
Back, M., Weber, C., Lutgens, E.
openaire   +2 more sources

Association between weight-adjusted waist index and carotid atherosclerotic plaque in patients with type 2 diabetes in the Chinese population

Diabetology & Metabolic Syndrome
Purpose The purpose of this study is to investigate the relationship between the weight-adjusted waist index (WWI) and the incidence of carotid atherosclerotic plaque in patients with type 2 diabetes (T2DM) in the Chinese population.
Yu Qin, Jing-Jing Ye, Xu-Nan Wu, Yue Xia, Hao-Xiang Li, Ling Yang, Xia Deng, Guo-Yue Yuan   +7 more
doaj   +1 more source