Results 21 to 30 of about 575,333 (346)
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers. Consistent basic data suggest that these same checkpoints are critical negative regulators of atherosclerosis ...
Z. Drobni +19 more
semanticscholar +1 more source
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed. Objective: Using single-cell
M. Depuydt +22 more
semanticscholar +1 more source
Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management. [PDF]
, 2020 Physical activity and exercise training are effective strategies for reducing the risk of cardiovascular events, but multiple studies have reported an increased prevalence of coronary atherosclerosis, usually measured as coronary artery calcification ...
Aengevaeren, VL +7 more
core +3 more sources
Effects of norepinephrine on plaque hypoxia in atherosclerotic rabbits
Frontiers in Cardiovascular Medicine, 2023 BackgroundHypoxia plays a vital role throughout the whole process of atherosclerotic vulnerable plaque formation, which may be induced by a reduced oxygen supply.
Jia-Yu Wang +4 more
doaj +1 more source
Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography [PDF]
, 2014 Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage ...
Abendschein, Dana R. +9 more
core +2 more sources
Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability
International Journal of Molecular Sciences, 2020 Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins.
W. Olejarz +2 more
semanticscholar +1 more source
Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques
Chinese Medical Journal, 2017 Objective: Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events ...
Xiang-Dong Xiong +3 more
doaj +1 more source
Utility of 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines in HIV-Infected Adults With Carotid Atherosclerosis. [PDF]
, 2017 BackgroundAlthough HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins.
Deeks, Steven +8 more
core +3 more sources
Science Translational Medicine, 2020 Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are
Wei Tao +11 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Atherosclerotic plaque vulnerability and rupture increase the risk of acute coronary syndromes. Advanced lesion macrophage apoptosis plays important role in the rupture of atherosclerotic plaque, and endoplasmic reticulum stress (ERS) has been proved to ...
Jin-Ling Ren +9 more
doaj +1 more source