Results 71 to 80 of about 575,333 (346)

Angiogenesis in the atherosclerotic plaque

Redox Biology, 2017
Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries characterized by a local accumulation of cholesterol and non-resolving inflammation.
Caroline Camaré, Mélanie Pucelle, A. Nègre-Salvayre, R. Salvayre   +3 more
semanticscholar   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Investigation for atherosclerotic plaque rupture with thrombosis in mice based on single-cell sequencing and bioinformatics analysis

Frontiers in Cardiovascular Medicine
IntroductionAtherosclerotic plaque rupture with thrombus formation leads to severe cardiovascular events. We hoped to explore the hub genes providing critical roles in the process of atherosclerotic plaque rupture accompanied by thrombus formation, which
Peng Nie, Fang Wan, Tianbao Yao, Yao Li, Guofeng Yan, Jun Pu, Shuxuan Jin   +6 more
doaj   +1 more source

Stages of atherosclerotic plaque development and unstable plaque types: pathophysiologic and histologic characteristics

Российский кардиологический журнал, 2013
This literature review focuses on the modern views on the problem of atherosclerotic plaque, its developmental stages (from the lipid steak to unstable atherosclerotic plaque), and various types of plaque instability (lipid, inflammatory, and ...
Yu. I. Ragino, A. M. Volkov, A. M. Chernyavskyi   +2 more
doaj   +1 more source

Atherosclerotic Plaque Rupture [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating lesions prone to plaque instability, such as “vulnerable plaque,” and the different phenotypes of unstable plaques, such as plaque rupture, plaque fissuring, intraplaque hemorrhage, and erosion, are ...
Esther, Lutgens, Robert-Jan, van Suylen, Birgit C, Faber, Marion J, Gijbels, Petra M, Eurlings, Ann-Pascale, Bijnens, Kitty B, Cleutjens, Sylvia, Heeneman, Mat J A P, Daemen   +8 more
openaire   +2 more sources

Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study. [PDF]

, 2018
Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk.
Brent Muhlestein, J, Budoff, Matthew, Le, Viet T, May, Heidi T, Nelson, John R, Roy, Sion   +5 more
core   +2 more sources

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Nature Communications, 2018
Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms regulating expansion and fate of pre-existing SMCs in atherosclerotic plaques remain poorly defined.
A. Misra, Zhonghui Feng, Rachana R. Chandran, Inamul Kabir, N. Rotllan, Binod Aryal, A. Sheikh, L. Ding, Lingfeng Qin, C. Fernández‐Hernando, G. Tellides, Daniel M. Greif   +11 more
semanticscholar   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Atherosclerosis is the most common form of vascular disease and constitutes the major cause of death, with 17.5 million related deaths annually (31% of global mortality).[1][1] Atherosclerotic plaque represents the hallmark lesion of atherosclerosis ...
C. Stefanadis, C. Antoniou, D. Tsiachris, P. Pietri   +3 more
semanticscholar   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source