Results 141 to 150 of about 382,869 (342)

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Classification of Carotid Plaque with Jellyfish Sign Through Convolutional and Recurrent Neural Networks Utilizing Plaque Surface Edges [PDF]

arXiv
In carotid arteries, plaque can develop as localized elevated lesions. The Jellyfish sign, marked by fluctuating plaque surfaces with blood flow pulsation, is a dynamic characteristic of these plaques that has recently attracted attention. Detecting this sign is vital, as it is often associated with cerebral infarction.
arxiv  

COMPARATIVE STUDY OFESCHERICHIA COLIPHAGE T1 AND A PLAQUE TYPE MUTANT [PDF]

, 1958
Ruth F. Hill
openalex   +1 more source

Secondary Plaque Over Primary Plaque on Scalp

Indian Dermatology Online Journal, 2021
Rashi Pangti, Neetu Bhari, Rhea Ahuja
openaire   +3 more sources

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

Relationship Between Characteristics of Stenotic Plaque in Carotid Artery and Ischemic Stroke Recurrence [PDF]

Türk Nöroloji Dergisi, 2007
OBJECTIVE: Quantification of stenosis, plaque morphology and surface characteristics by doppler sonography and prediction of plaque rupture risk are important for treatment options in ischemic stroke.
Semai Bek, Şeref Demirkaya, Kemal Hamamcıoğlu, Oğuzhan Öz, Zeki Odabaşı, Okay Vural   +5 more
doaj  

Parapsoriasis en Plaques Treated with Calciferol [PDF]

, 1948
H. W. Barber, David Erskine
openalex   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

WAL-Net: Weakly supervised auxiliary task learning network for carotid plaques classification [PDF]

arXiv
The classification of carotid artery ultrasound images is a crucial means for diagnosing carotid plaques, holding significant clinical relevance for predicting the risk of stroke. Recent research suggests that utilizing plaque segmentation as an auxiliary task for classification can enhance performance by leveraging the correlation between segmentation
arxiv  

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source