Results 21 to 30 of about 1,082,648 (349)
Nature Communications, 2019 Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Elizabeth E. Spangenberg +21 more
semanticscholar +1 more source
Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study [PDF]
American Journal of Neuroradiology, 2020 Plaque ulceration is a marker of previous plaque rupture. We studied the association between atherosclerotic plaque composition at baseline and plaque ulceration at baseline and follow-up.We included symptomatic patients with a carotid stenosis of
K. Dilba +10 more
openaire +6 more sources
Calcifications in atherosclerotic plaques and impact on plaque biomechanics
Journal of Biomechanics, 2019 The catastrophic mechanical rupture of an atherosclerotic plaque is the underlying cause of the majority of cardiovascular events. The infestation of vascular calcification in the plaques creates a mechanically complex tissue composite. Local stress concentrations and plaque tissue strength properties are the governing parameters required to predict ...
Barrett, Hilary E. +4 more
openaire +3 more sources
Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque [PDF]
, 2018 Experimental studies showed that gut-derived lipopolysaccharide (LPS) is pro-atherogenic, however, its relationship with human atherosclerosis is still to be defined.
Cammisotto, Vittoria +11 more
core +2 more sources
Oral plaque from Type 2 diabetic patients reduces the clonogenic capacity of dental pulp-derived mesenchymal stem cells [PDF]
, 2019 Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and ...
Bordin, Antonella +9 more
core +1 more source
Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
Nature Neuroscience, 2018 Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2.
S. Parhizkar +28 more
semanticscholar +1 more source
Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study. [PDF]
, 2018 Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk.
Brent Muhlestein, J +5 more
core +2 more sources
Science Translational Medicine, 2020 Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are
Wei Tao +11 more
semanticscholar +1 more source