Results 51 to 60 of about 1,146,198 (394)

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The role of p53 in atherosclerosis [PDF]

, 2006
Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular,
Bennett, M., Mercer, J.R.
core   +1 more source

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Science Translational Medicine, 2020
Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are
Wei Tao, Arif Yurdagul, Na Kong, Wenliang Li, Xiaobo Wang, Amanda C. Doran, Chan Feng, Junqing Wang, M. Islam, O. Farokhzad, I. Tabas, Jinjun Shi   +11 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A New Approach in Risk Stratification by Coronary CT Angiography. [PDF]

, 2014
For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks.
Budoff, Matthew J, Nakanishi, Rine
core   +3 more sources

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

International Journal of Molecular Sciences, 2020
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins.
W. Olejarz, Dominika Łacheta, Grażyna Kubiak-Tomaszewska   +2 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease [PDF]

, 2019
Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD).
Dodel, Richard, Du, Eileen, Du, Yansheng, Farlow, Martin R., Gu, Huiying, Kirchhein, Yvonne, Liu, Junyi, Mastrianni, James A., Peng, Hongjun, Zhao, Gang, Zhu, Timothy   +10 more
core   +1 more source

Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study.

European Heart Journal, 2019
AIMS The CLIMA study, on the relationship between coronary plaque morphology of the left anterior descending artery and twelve months clinical outcome, was designed to explore the predictive value of multiple high-risk plaque features in the same ...
F. Prati, E. Romagnoli, L. Gatto, A. L. La Manna, F. Burzotta, Y. Ozaki, V. Marco, A. Boi, M. Fineschi, F. Fabbiocchi, N. Taglieri, G. Niccoli, C. Trani, F. Versaci, G. Calligaris, Gianni Ruscica, A. Di Giorgio, R. Vergallo, M. Albertucci, G. Biondi-Zoccai, C. Tamburino, F. Crea, F. Alfonso, E. Arbustini   +23 more
semanticscholar   +1 more source