Results 61 to 70 of about 368,495 (267)

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

The action of ginsenoside Rg1 in patients with carotid atherosclerosis: a controlled clinical trial

Frontiers in Pharmacology
ObjectiveThis study evaluated therapeutic effects of ginsenoside Rg1 (QiShengli Tablets) in patients with carotid artery plaques, in combination with lifestyle interventions, lipid-lowering therapy.
Xu Fang, Xuan Ma, Xuan Ma, Man Zhang, Li Zhang, Xu He, Shilei Liu, Yinsong Dong, Yan Li, Junzi Wu, Junzi Wu   +10 more
doaj   +1 more source

Anti‐CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non‐Active Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine, Fabien Rollot, Romain Casey, Nicolas Collongues, Sandra Vukusic, Guillaume Mathey, Anne Laure Dubessy, Jonathan Ciron, Jérôme De Seze, Aurélie Ruet, Pierre Labauge, Arnaud Kwiatkowski, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun‐Frenay, David Axel Laplaud, Eric Berger, Eric Thouvenot, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Abir Wahab, Laurent Magy, Jean‐Philippe Camdessanché, Ines Doghri, Solène Moulin, Mariana Sarov Rivière, Karolina Hankiewicz, Amélie Dos Santos, Corinne Pottier, Eric Manchon, Jennifer Aboab, Maia Tchikviladze, Thomas David, Gilles Edan, Emmanuelle Le Page, Laure Michel, Anne Kerbrat, OFSEP Investigators   +40 more
wiley   +1 more source

Psychological stress: Its effect on periodontal status of individuals

Journal of Dr. NTR University of Health Sciences, 2015
Background: Periodontitis is the inflammation and infection of the tissues that support the teeth. Growing evidence suggests that the psychosocial factors such as stress, depression, and level of social support provoke changes in host defense mechanisms ...
Gagan R Jaiswal, Shradha G Jaiswal
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Combining Biomarkers and Imaging for Short‐Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Current strategies for cardiovascular disease (CVD) risk assessment focus on 10‐year or longer timeframes. Shorter‐term CVD risk is also clinically relevant, particularly for high‐risk occupations, but is under‐investigated.
Maria Odette Gore, Colby R. Ayers, Amit Khera, Christopher R. deFilippi, Thomas J. Wang, Stephen L. Seliger, Vijay Nambi, Elizabeth Selvin, Jarett D. Berry, W. Gregory Hundley, Matthew Budoff, Philip Greenland, Mark H. Drazner, Christie M. Ballantyne, Benjamin D. Levine, James A. de Lemos   +15 more
doaj   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Comparative evaluation of herbal extract-containing mouthwash on periodontal parameters: A randomized controlled trial

SRM Journal of Research in Dental Sciences
Background: Plaque is the main causative agent in the onset and progression of periodontal diseases and is directly linked to the development of gingivitis.
Harsh D. Borundia, Surekha Rathod, Savita Sharma, Shivani Koli   +3 more
doaj   +1 more source

Periodontal Diseases in Children and Adolescents

Česká Stomatologie a Praktické Zubní Lékařství, 2008
Periodontal diseases are the most common chronic conditions affecting the human race. Recently, increased attention has been given to these diseases because they were found to be related not only to oral health but also to many systemic diseases such as ...
K. Musilová, M. Kukletová, L. Izakovičová Hollá   +2 more
doaj