Results 91 to 100 of about 13,195 (242)

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, EarlyView.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Association between periodontitis and oral health–related quality of life in patients with systemic conditions: A meta‐analysis

Journal of Periodontology, EarlyView.
Abstract Background The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health–related quality of life (OHRQoL) in adults with systemic conditions. Methods Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical ...
Rafael Vargas Bortolaso, Catiusse Crestani Del' Agnese, Leandro Machado Oliveira, Patricia A. Miguez, Fabricio Batistin Zanatta, Raquel Pippi Antoniazzi   +5 more
wiley   +1 more source

The immune system in atherosclerosis and in acute myocardial infarction

Heart International, 2006
Acute myocardial infarction (AMI) occurs when the atheromatous process prevents total blood flow through the coronary artery. It was previously thought that progressive luminal narrowing from the continued growth of smooth muscle cells (SMCs) in the ...
Antonio Barsotti, Francesco Indiveri, Massimiliano Fedele, Patrizia Fabbi, Matteo Vercellino   +4 more
doaj   +1 more source

Smoking effects on root coverage outcomes between 3 and 12 months: A prospective cohort study

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the impact of smoking on root coverage outcomes, comparing healing responses at 3–12 months following coronally advanced flap with a connective tissue graft (CAF+CTG). Methods This prospective cohort study included 27 participants (13 smokers, 14 non‐smokers) who required root coverage for a single Cairo
Hande Has‐Elci, Duygu Taş, Zeliha Güney, Merve Atak, Sivge Kurgan, Muhittin A. Serdar, Dimitris N. Tatakis   +6 more
wiley   +1 more source

Zinc‐stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram‐negative species, and overall inflammation within an experimental gingivitis clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the effects of a dentifrice containing stannous fluoride stabilized with zinc phosphate on subgingival microbiome composition and clinical inflammation during experimental gingivitis, compared with a sodium fluoride control. Methods This investigation was conducted as a secondary analysis of a randomized,
Kristopher A. Kerns, Allison A. Naumann, Lay Y. Soon, Erik L. Hendrickson, Abdelahhad Barbour, Dandan Chen, Harsh M. Trivedi, Michael Glogauer, Jeffrey S. McLean   +8 more
wiley   +1 more source

Jewelled Byzantine and Medieval Reliquaries of the True Cross: Peridots and Other Gemstones in Material and Symbolic Perspective

Journal of Raman Spectroscopy, EarlyView.
An interdisciplinary in situ study of jewelled reliquaries of the True Cross integrates gemmology and portable analytical techniques, revealing new evidence on the identification and symbolic role of peridots and other gemstones. ABSTRACT Jewelled crosses containing relics of the True Cross occupy a central position in the devotional, artistic and ...
Stefania Martiniello, Stefano Legnaioli, Simona Raneri   +2 more
wiley   +1 more source

Comprehensive age-specific metabolic phenotyping in myocardial infarction

BMC Cardiovascular Disorders
Aging is a main risk factor for the development of myocardial infarction (MI), with worse clinical outcomes. However, the understanding of age-related metabolic profiles in MI remains unclear. This study aimed to identify the clinical implications of age-
Xiaoxuan Bai, Ming Zeng, Tianyu Wu, Ying Lv, Chen Zhao, Xing Luo, Boling Yi, Huahui Ren, Yixuan Zhang, Liangxiao Xu, Xiuzhu Weng, Shan Zhang, Yuxiao Zhu, Sining Hu, Bo Yu, Haibo Jia   +15 more
doaj   +1 more source

Successful Co‐Administration of Secukinumab and Dupilumab in a Patient With Psoriasis and Paradoxical Atopic Dermatitis

JEADV Clinical Practice, EarlyView.
ABSTRACT Paradoxical atopic dermatitis (AD) can arise during biologic therapy for psoriasis due to an immune‐axis imbalance. We describe a 47‐year‐old man who developed severe AD while receiving secukinumab, which was successfully managed with the addition of dupilumab, allowing long‐term control of both diseases.
So Yun Park, Minjung Park, Ho Eun Gwang, Narang Hong, Hye Jung Jung, Mi Youn Park, Jiyoung Ahn   +6 more
wiley   +1 more source