Results 71 to 80 of about 117,541 (261)

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

The triglyceride-glucose index is associated with coronary plaque features and clinical outcomes in patients with ST-segment elevation myocardial infarction

Frontiers in Endocrinology
BackgroundThe triglyceride-glucose (TyG) index is a reliable surrogate marker for insulin resistance, and is associated with cardiovascular diseases. However, the specific impact of TyG index on coronary plaque vulnerability and long-term outcomes in ...
Yibo Guo, Yibo Guo, Yibo Guo, Lina Cui, Lina Cui, Lina Cui, Jiaqing Guo, Jiaqing Guo, Jiaqing Guo, Chengmei Jin, Chengmei Jin, Chengmei Jin, Lili Xiu, Lili Xiu, Lili Xiu, Yubo Gao, Yubo Gao, Yubo Gao, Chen Zhao, Chen Zhao, Chen Zhao, Xueming Xu, Xueming Xu, Xueming Xu, Jinfeng Tan, Jinfeng Tan, Jinfeng Tan, Jincheng Han, Jincheng Han, Jincheng Han, Lulu Li, Lulu Li, Lulu Li, Tao Chen, Tao Chen, Tao Chen, Jiannan Dai, Jiannan Dai, Jiannan Dai, Bo Yu, Bo Yu, Bo Yu, Chao Fang, Chao Fang, Chao Fang   +44 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

INSTRUKSI KONTROL PLAK DAN SKALING SEBAGAI METODE PERAWATAN GINGIVITIS PUBERTAS PADA SANTRI PONDOK PESANTREN

Jurnal Ilmu Kesehatan Masyarakat, 2015
The prevalence of gingivitis increased in the puberty periods (Puberty gingivitis). Most of students of pesantren were in puberty age. The students of pesantren have a limited access to get periodontal treatment. This study evaluated the effectiveness of
Yuliana Mahdiyah Da’at Arina
doaj  

Association of triglyceride-glucose index with carotid atherosclerosis in the general population: a case-control study of 14,535 participants

BMC Cardiovascular Disorders
Background Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide, with increased carotid intima-media thickness (CIMT) and carotid plaque serving as key markers of subclinical atherosclerosis. The triglyceride glucose (
Hong Wang, Zhihong Ma, Siqi Ge, Junping Tian   +3 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

A Novel Dental Plaque Index Using Intraoral Camera Images

치위생과학회지
Background: This study aimed to evaluate whether a Novel Plaque Index (NPI) using intraoral camera images would be more useful for assessing the accumulated area of dental plaque compared to three other indices.
Ji-Soo Kim
doaj   +1 more source

The effectiveness of water jet flossing and interdental flossing for oral hygiene in orthodontic patients with fixed appliances: a randomized clinical trial

BMC Oral Health
Background Orthodontic treatment presents challenges with plaque accumulation around brackets, archwires, and elastics, leading to retained plaque and gingival inflammation.
Hani S. AlMoharib, Afyaa Alqasem, Ghaida Almusfer, Mohammad A. Aldosari, Hossam Waleed Almadhoon   +4 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source