Results 91 to 100 of about 230,540 (304)

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Sivas il merkezi özel ve devlet okullarındaki 12-17 yaş grubu öğrencilerin periodontal tedavi gereksiniminin ve dolgu ihtiyaçlarının karşılaştırılması

Cumhuriyet Dental Journal, 2011
<p><strong>Objective:</strong> The purpose of this study was to determine the periodontal treatment needs, using the CPITN and tooth decay, in 12-17 years old children from private and public schools from Sivas.</p> <p>< ...
Ziynet Cinar, A Hakan Develioglu, Vildan Bostanci   +2 more
doaj   +1 more source

Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives. [PDF]

, 2019
Tofacitinib is an oral Janus kinase inhibitor approved for the treatment of psoriatic arthritis (PsA). It provides an alternative option for patients who have had an inadequate response and tolerance to other disease modifying antirheumatic drugs (DMARDs)
Beck, Kristen M, Liao, Wilson, Ly, Karen, Orbai, Ana-Maria, Smith, Mary P   +4 more
core  

A Systematic Review on the Implication of Minerals in the Onset, Severity and Treatment of Periodontal Disease [PDF]

, 2016
Periodontal disease is an inflammatory disease with high prevalence in adults that leads to destruction of the teeth-supporting tissues. Periodontal therapy has been traditionally directed at reduction of the bacterial load to a level that encourages ...
Battino, Maurizio, Bullon, Pedro, Giampieri, Francesca, Quiles, José L., Valera-López, Alfonso   +4 more
core   +5 more sources

DeepPlaq: Dental plaque indexing based on deep neural networks

Clinical Oral Investigations
Abstract Objectives This study aimed to detect and segment target teeth and score on each individual teeth according to the Quigley-Hein plaque index (QHI) by using multi-view intraoral images and a deep learning approach. Material and Methods A dataset of intraoral images captured from both frontal and lateral views of permanent and ...
Xu, Chen, Yiran, Shen, Jin-Sun, Jeong, Hiran, Perinpanayagam, Kee-Yeon, Kum, Yu, Gu   +5 more
openaire   +2 more sources

Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration

Advanced Materials, EarlyView.
A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang, Byeongseok Ryu, Sujeong Ahn, Junhyub Kim, Myeonghun Jang, Jeong Ho Cho, Won‐Gun Koh, Hyungsuk Lee   +7 more
wiley   +1 more source

The triglyceride-glucose index is associated with coronary plaque features and clinical outcomes in patients with ST-segment elevation myocardial infarction

Frontiers in Endocrinology
BackgroundThe triglyceride-glucose (TyG) index is a reliable surrogate marker for insulin resistance, and is associated with cardiovascular diseases. However, the specific impact of TyG index on coronary plaque vulnerability and long-term outcomes in ...
Yibo Guo, Yibo Guo, Yibo Guo, Lina Cui, Lina Cui, Lina Cui, Jiaqing Guo, Jiaqing Guo, Jiaqing Guo, Chengmei Jin, Chengmei Jin, Chengmei Jin, Lili Xiu, Lili Xiu, Lili Xiu, Yubo Gao, Yubo Gao, Yubo Gao, Chen Zhao, Chen Zhao, Chen Zhao, Xueming Xu, Xueming Xu, Xueming Xu, Jinfeng Tan, Jinfeng Tan, Jinfeng Tan, Jincheng Han, Jincheng Han, Jincheng Han, Lulu Li, Lulu Li, Lulu Li, Tao Chen, Tao Chen, Tao Chen, Jiannan Dai, Jiannan Dai, Jiannan Dai, Bo Yu, Bo Yu, Bo Yu, Chao Fang, Chao Fang, Chao Fang   +44 more
doaj   +1 more source

Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date. [PDF]

, 2018
Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the United States. Advances over the past 20 years in understanding the immune-mediated pathophysiology of psoriasis have led to the development of targeted biologic
Beck, Kristen M, Liao, Wilson, Sanchez, Isabelle M, Yang, Eric J   +3 more
core