Results 31 to 40 of about 755,810 (388)

Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment–Elevation Myocardial Infarction

Circulation. Cardiovascular Interventions, 2019
Background Trimethylamine N-oxide (TMAO) is reported to promote the pathogenesis of atherosclerosis and be associated with cardiovascular events risk.
Yu Tan, Z. Sheng, P. Zhou, Chen Liu, Hanjun Zhao, Li Song, Jiannan Li, Jinying Zhou, Yi Chen, Laiyuan Wang, H. Qian, Zhongwei Sun, S. Qiao, Bo Xu, R. Gao, Hongbing Yan   +15 more
semanticscholar   +1 more source

Seasonal Variations in the Pathogenesis of Acute Coronary Syndromes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Seasonal variations in acute coronary syndromes (ACS) have been reported, with incidence and mortality peaking in the winter. However, the underlying pathophysiology for these variations remain speculative.
Osamu Kurihara, Masamichi Takano, Erika Yamamoto, Taishi Yonetsu, Tsunekazu Kakuta, Tsunenari Soeda, Bryan P. Yan, Filippo Crea, Takumi Higuma, Shigeki Kimura, Yoshiyasu Minami, Tom Adriaenssens, Niklas F. Boeder, Holger M. Nef, Chong Jin Kim, Vikas Thondapu, Hyung Oh Kim, Michele Russo, Tomoyo Sugiyama, Francesco Fracassi, Hang Lee, Kyoichi Mizuno, Ik‐Kyung Jang   +22 more
doaj   +1 more source

Evolution and rupture of vulnerable plaques: a review of mechanical effects [PDF]

, 2013
Atherosclerosis occurs as a result of the buildup and infiltration of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is of critical importance, since plaque rupture can result ...
Assemat, Pauline, Hourigan, Kerry
core   +2 more sources

The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture

British Journal of Pharmacology, 2020
The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant limitations in our understanding and ability to identify unstable plaque pathology and prevent plaque rupture, most ...
J. Noonan, A. Bobik, K. Peter
semanticscholar   +1 more source

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

Clinical Proteomics, 2017
Background Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding and clinical management of ...
Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler, Keith M. Channon   +10 more
doaj   +1 more source

Importance of inflammation in arteriosclerotic plaque destabilization and rupture [PDF]

Vojnosanitetski Pregled, 2005
Introduction. Although Rudolf Virchow considered arteriosclerosis an inflammatory disease in his book Cellular Pathology published in 1858, the opinion that it was a degenerative arterial disease as a civilization disease prevailed.
Tatić Vujadin, Kanjuh Vladimir, Rafajlovski Saša I., Kostić Kristina, Šuščević Dušan   +4 more
doaj   +1 more source

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

BMC Cardiovascular Disorders, 2019
Background The association between mean platelet volume (MPV) and coronary plaque vulnerability in patients with non-ST-elevation ACS (NSTE-ACS) has not been investigated.
Jun Wang, Xing Li, Jun Pu, Siyu Jin, Lu Jia, Xiaomei Li, Fen Liu, Yining Yang   +7 more
doaj   +1 more source

The role of p53 in atherosclerosis [PDF]

, 2006
Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular,
Bennett, M., Mercer, J.R.
core   +1 more source

Studying the Factors of Human Carotid Atherosclerotic Plaque Rupture, by Calculating Stress/Strain in the Plaque, Based on CEUS Images: A Numerical Study

Frontiers in Neuroinformatics, 2020
Carotid plaque neovascularization is one of the major factors for the classification of vulnerable plaque, but the axial force effects of the pulsatile blood flow on the plaque with neovessel and intraplaque hemorrhage was unclear.
Zhenzhou Li, Yongfeng Wang, Xinyin Wu, Xin Liu, Shanshan Huang, Yi He, Shuyu Liu, Lijie Ren   +7 more
doaj   +1 more source

Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3 [PDF]

, 2017
In previous work we reported that ApoeKO mice transplanted with bone marrow cells deficient in the Transient Receptor Potential Canonical 3 (TRPC3) channel have reduced necrosis and number of apoptotic macrophages in advanced atherosclerotic plaques ...
Birnbaumer, Lutz, Dube, Prabhatchandra R., Solanki, Sumeet, Vazquez, Guillermo   +3 more
core   +1 more source