Results 111 to 120 of about 162,485 (319)

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Evaluation of Intensive Statins and Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Intracranial Artery Plaque Stability: A Prospective Single‐Arm Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Intracranial atherosclerotic stenosis is a leading cause of ischemic stroke and recurrent events due to plaque instability. High‐resolution magnetic resonance imaging identifies plaque enhancement as a key marker of instability.
Weiqi Zeng, Feng Zhou, Hai Zhao, Yukai Wang, Jingjuan Chen, Jiancong Lu, Dezhi Zheng, Jingyun Kuang, Dahua Yuan, Jing Zhou, Changzheng Shi, Xihai Zhao, Xinyi Leng, Bernard Yan, Zefeng Tan   +14 more
doaj   +1 more source

Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells

Frontiers in Pharmacology, 2017
Atherosclerosis (AS) is a lipid-driven disease in which macrophage foam cells play a critical role by increasing vascular lipid accumulation and contributing to plaque instability. Ginsenoside Rb1 (Rb1), the most abundant active component of ginseng, has
Lei Qiao, Xue Zhang, Xue Zhang, Minghao Liu, Xiaoling Liu, Mei Dong, Jing Cheng, Xinyu Zhang, Chungang Zhai, Yu Song, Huixia Lu, Wenqiang Chen   +11 more
doaj   +1 more source

The Role of Biomarkers on Haemodynamics in Atherosclerotic Artery [PDF]

arXiv
Atherosclerosis, a chronic inflammatory cardiovascular disease, leads to arterial constriction caused by the accumulation of lipids, cholesterol, and various substances within artery walls. Such plaque can rupture, resulting in a blood clot that obstructs major arteries and may initiate myocardial infarction, ischemic stroke, etc.
arxiv  

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease

Advanced Science, EarlyView.
High‐throughput proteoform imaging (HTPi) is established by combining matrix‐assisted laser desorption ionization mass spectrometry imaging and high‐sensitivity region‐specific top‐down proteomic analysis. HTPi enables the generation of annotated proteoform images with exceptional precision, high throughput, and deep coverage, showing distinct spatial ...
Yue Sun, Dan Liu, Yu Liang, Xue Yang, Xinxin Liu, Baofeng Zhao, Zhen Liang, Yukui Zhang, Lihua Zhang   +8 more
wiley   +1 more source

Localization of Tissue Transglutaminase in Human Carotid and Coronary Artery Atherosclerosis: Implications for Plaque Stability and Progression [PDF]

, 2001
Zishan A. Haroon, Thomas Wannenburg, Madhu Gupta, Charles S. Greenberg, Reidar Wallin, David C. Sane   +5 more
openalex   +1 more source

A mathematical model for smooth muscle cell phenotype switching in atherosclerotic plaque [PDF]

arXiv
Smooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. SMCs may ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the plaque. This can stimulate SMCs to undergo a phenotypic switch towards a macrophage-like phenotype.
arxiv  

Efficient Parallel Simulation of Atherosclerotic Plaque Formation Using Higher Order Discontinuous Galerkin Schemes [PDF]

arXiv, 2014
The compact Discontinuous Galerkin 2 (CDG2) method was successfully tested for elliptic problems, scalar convection-diffusion equations and compressible Navier-Stokes equations. In this paper we use the newly developed DG method to solve a mathematical model for early stages of atherosclerotic plaque formation.
arxiv  

Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis

Advanced Science, EarlyView.
This study presents decursin, a traditional Chinese medicine monomer, that inhibits lipid accumulation and inflammation in atherosclerosis through PKCδ interaction. A novel targeted delivery system (ALD@EM) is developed to overcome decursin's short half‐life, combining antibody‐mediated targeting, LDL‐facilitated chemotaxis, and enhanced macrophage ...
Hui Chen, Yifeng Zhang, Mirenuer Aikebaier, Yawei Du, Yan Liu, Qing Zha, Lan Zheng, Shuyao Shan, Yanping Wang, Jiawei Chen, Yiping Li, Ke Yang, Ying Yang, Wenguo Cui   +13 more
wiley   +1 more source