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Stroke, 2012 Background and Purpose— Recent studies have investigated plaque morphology to determine patients who are at high risk of carotid atherosclerosis.
Minoru Morikawa +2 more
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European Journal of Cardiovascular Prevention & Rehabilitation, 2003
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are now the standard of care for patients with hypercholesterolaemia. This class of inhibitors, known as 'statins', has been shown to reduce cardiovascular morbidity and mortality. Accumulating data demonstrates a variety of mechanisms in which HMG-CoA reductase inhibition benefits ...
Mardi, Gomberg-Maitland +4 more
openaire +2 more sources
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are now the standard of care for patients with hypercholesterolaemia. This class of inhibitors, known as 'statins', has been shown to reduce cardiovascular morbidity and mortality. Accumulating data demonstrates a variety of mechanisms in which HMG-CoA reductase inhibition benefits ...
Mardi, Gomberg-Maitland +4 more
openaire +2 more sources
Mechanisms of plaque stabilization with statins
The American Journal of Cardiology, 2003The traditional view of cardiovascular disease held that the degree of stenosis defined high-risk lesions and that removal of cholesterol shrank these lesions and thereby enlarged the lumen. Advances in understanding of the pathophysiology of the acute coronary syndromes refute this view.
Peter, Libby, Masanori, Aikawa
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Macrophages and atherosclerotic plaque stability
Current Opinion in Lipidology, 1996Physical disruption of atheroma frequently causes coronary thrombosis. Ruptured plaques usually have thin fibrous caps overlying a large thrombogenic lipid core rich in lipid-laden macrophages. The biology of plaque monocyte-derived macrophages thus assumes critical importance in understanding plaque instability.
P, Libby +7 more
openaire +2 more sources
Atherosclerotic Plaque Stability—What Determines the Fate of a Plaque?
Progress in Cardiovascular Diseases, 2008Although the understanding of the underlying pathology of atherosclerosis has improved in recent years, the disease is still the main cause of death globally. Current evidence has implicated the role of inflammation in atherogenesis and plaque destabilization.
Bente, Halvorsen +6 more
openaire +2 more sources
PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION
Cardiology Clinics, 1996Atherosclerotic coronary artery disease is the major cause of death, in men and women, in the United States and in much of the Western world. Atherosclerosis is responsible for coronary heart disease, limb ischemia, and most strokes. Although luminal narrowing by an atherosclerotic plaque and exaggerated or anomalous vasoconstriction contribute to some
openaire +3 more sources
Atherosclerotic plaque stabilization and regression
VasaSummary: Atherosclerotic plaques represent a typical deterioration of arterial wall in atherosclerotic process and are the source of cardiovascular events. Plaque progression and composition represent a major risk for cardiovascular events. Therefore, recently many studies have assessed changes in plaque characteristics and their response to various ...
Pavel Poredoš +2 more
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Plaque stabilizing effects of apolipoprotein A-IV
Atherosclerosis, 2016Apolipoprotein (apo) A-IV, the third most abundant HDL-associated protein, is atheroprotective and shares similar properties as apoA-I. We have reported previously that apoA-I, the most abundant apolipoprotein in HDL, inhibits plaque disruption in a mouse model. We aimed at examining the effects of apoA-IV on markers of plaque stability in vivo.Plaques
F.R.B. Geronimo +5 more
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Regression and stabilization of atherogenic plaques
Trends in Cardiovascular MedicineAtherosclerotic plaque assessment has become a crucial element in the examination of cardiovascular diseases. Plaque may exhibit progression and could become unstable if not treated, making plaque regression and stabilization among the most important goals of any cardiovascular intervention in cardiovascular medicine.
Jairo Aldana-Bitar +2 more
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2006
The association between elevated low density lipoprotein (LDL) cholesterol and atherothrombotic vascular disease is well established. Lipid-lowering therapies reduce cardiovascular events; however, the mechanism of benefit attributable to HMG CoA reductase inhibitors likely transcends lipids alone by directly or indirectly affecting inflammatory ...
Richard C. Becker, Frederick A. Spencer
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The association between elevated low density lipoprotein (LDL) cholesterol and atherothrombotic vascular disease is well established. Lipid-lowering therapies reduce cardiovascular events; however, the mechanism of benefit attributable to HMG CoA reductase inhibitors likely transcends lipids alone by directly or indirectly affecting inflammatory ...
Richard C. Becker, Frederick A. Spencer
openaire +1 more source