Results 151 to 160 of about 78,612 (185)

Update in Therapeutic Approaches to Plaque Stabilization

Current Atherosclerosis Reports, 2014
Increasing pathological insights have highlighted the role of plaque instability in the pathogenesis of acute ischemic syndromes. These studies have identified a specific plaque phenotype, characterized by large burden, expansive arterial wall remodeling, and greater composition of lipid, inflammatory, and necrotic material, as the disease most likely ...
Stephen J, Nicholls, Yu, Kataoka
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Plaque Stability and the Southern European Paradox

Revista Española de Cardiología (English Edition), 2013
Differences between European countries in coronary heart disease mortality were initially described in the 20th century, and albeit less dramatic than first reported, these differences remain substantial. Three main hypotheses have been proposed to explain the so-called "Mediterranean paradox": a) underestimation of coronary heart disease mortality due
Irene R, Dégano, Roberto, Elosua, Juan C, Kaski, Daniel J, Fernández-Bergés, María, Grau, Jaume, Marrugat   +5 more
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Carotid Atherosclerotic Plaques Stabilize After Stroke

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— Rupture of unstable atherosclerotic plaques is the pathological substrate for acute ischemic events. Underlying cellular and molecular characteristics of plaque rupture have been studied extensively.
W, Peeters, W E, Hellings, D P V, de Kleijn, J P P M, de Vries, F L, Moll, A, Vink, G, Pasterkamp   +6 more
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Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability

Archives of Biochemistry and Biophysics, 2020
Our previous research revealed that trypsin is abundantly expressed in atherosclerotic plaques and its distribution overlaps with that of matrix metalloproteinase-9 (MMP-9). This study was performed to explore the possible roles of trypsin in vulnerable atherosclerotic plaque formation.Twenty-four rabbits were randomly assigned to a normal (control ...
Jia-Yu, Shi, Hai-Yan, Pan, Kun, Liu, Min, Pan, Guo-Jun, Si   +4 more
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[Plaque stabilization by LDL apheresis?].

Herz, 1999
Vulnerable lipid-rich plaques are often the cause of atherothrombotic events leading to unstable angina and/or to acute myocardial infarction. Consequent long-term LDL-lowering by drugs as shown by the most important intervention studies lead to plaque stabilization as shown by the significant reduction of myocardial reinfarction.
P, Schuff-Werner, V, Schettler
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[Mechanisms of plaque stabilization].

Herz, 1999
Numerous angiographic control regression studies have demonstrated that aggressive reduction of plasma cholesterol significantly reduces the incidence of clinical overt cardiovascular complications, but has almost no effect on the angiographically determined luminal diameter of the coronary arteries.
D, Müller-Wieland, M, Faust, J, Kotzka, W, Krone   +3 more
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Plaque stabilization: the role of lipid lowering

International Journal of Cardiology, 2000
The unstable atheroma characteristically has a thin, eccentric fibrous cap and a large necrotic core of lipid and cellular debris. This plaque configuration is particularly unstable because large mechanical stresses develop in the thinnest portions of the fibrosis cap over the lipid pool.
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Intracoronary Cryotherapy for Vulnerable Plaque Stabilization

Cardiology in Review
Acute coronary syndromes most commonly arise from rupture of biologically vulnerable, rather than hemodynamically severe, coronary plaques. Advances in intravascular and noninvasive imaging techniques, including intravascular ultrasound, optical coherence tomography, near-infrared spectroscopy, and coronary computed tomography angiography, have enabled
Nabel Rajab, Basha, Rimsha, Ahmad, Saifullah, Khan, Ruaa, Alsaeed, William H, Frishman, Wilbert S, Aronow   +5 more
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Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits

Cardiovascular Pathology, 2009
Fibrates are peroxisome proliferator-activated receptor alpha (PPARalpha) agonists which modulate many aspects of lipoprotein metabolism and inflammation. They have been recently demonstrated to inhibit in vitro expression of tissue factor (TF), the main initiator of blood coagulation, which probably plays a pivotal role in thrombotic complications ...
Emmanuelle, Jeanpierre, Thierry, Le Tourneau, Christophe, Zawadzki, Eric, Van Belle, Frederic, Mouquet, Sophie, Susen, Michael D, Ezekowitz, Bart, Staels, Brigitte, Jude, Delphine, Corseaux   +9 more
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Plaque Stability and Carotid Stenting

2009
Carotid angioplasty and stenting (CAS) is increasingly being performed for the treatment of severely stenotic carotid disease [1–5]. Despite, this growing acceptance, the recently published data of the Eva-3S trial [6], performed in France, and the SPACE trial [7] in Germany failed to prove superiority of CAS over CEA.
M. Bosiers, K. Deloose, P. Peeters
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