Results 241 to 250 of about 2,493,525 (282)

Atherosclerotic Plaque Stability—What Determines the Fate of a Plaque?

Progress in Cardiovascular Diseases, 2008
Although the understanding of the underlying pathology of atherosclerosis has improved in recent years, the disease is still the main cause of death globally. Current evidence has implicated the role of inflammation in atherogenesis and plaque destabilization.
Bente, Halvorsen, Kari, Otterdal, Tuva B, Dahl, Mona, Skjelland, Lars, Gullestad, Erik, Øie, Pål, Aukrust   +6 more
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PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION

Cardiology Clinics, 1996
Atherosclerotic coronary artery disease is the major cause of death, in men and women, in the United States and in much of the Western world. Atherosclerosis is responsible for coronary heart disease, limb ischemia, and most strokes. Although luminal narrowing by an atherosclerotic plaque and exaggerated or anomalous vasoconstriction contribute to some
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Atherosclerotic plaque stabilization and regression

Vasa
Summary: Atherosclerotic plaques represent a typical deterioration of arterial wall in atherosclerotic process and are the source of cardiovascular events. Plaque progression and composition represent a major risk for cardiovascular events. Therefore, recently many studies have assessed changes in plaque characteristics and their response to various ...
Pavel Poredoš, Ana Spirkoska Mangaroska, Peter Poredoš   +2 more
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Plaque-Stabilizing Therapies

2006
The association between elevated low density lipoprotein (LDL) cholesterol and atherothrombotic vascular disease is well established. Lipid-lowering therapies reduce cardiovascular events; however, the mechanism of benefit attributable to HMG CoA reductase inhibitors likely transcends lipids alone by directly or indirectly affecting inflammatory ...
Richard C. Becker, Frederick A. Spencer
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Regression and stabilization of atherogenic plaques

Trends in Cardiovascular Medicine
Atherosclerotic plaque assessment has become a crucial element in the examination of cardiovascular diseases. Plaque may exhibit progression and could become unstable if not treated, making plaque regression and stabilization among the most important goals of any cardiovascular intervention in cardiovascular medicine.
Jairo Aldana-Bitar, Deepak L. Bhatt, Matthew J. Budoff   +2 more
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Plaque Stability and the Southern European Paradox

Revista Española de Cardiología (English Edition), 2013
Differences between European countries in coronary heart disease mortality were initially described in the 20th century, and albeit less dramatic than first reported, these differences remain substantial. Three main hypotheses have been proposed to explain the so-called "Mediterranean paradox": a) underestimation of coronary heart disease mortality due
Irene R, Dégano, Roberto, Elosua, Juan C, Kaski, Daniel J, Fernández-Bergés, María, Grau, Jaume, Marrugat   +5 more
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Plaque stabilizing effects of apolipoprotein A-IV

Atherosclerosis, 2016
Apolipoprotein (apo) A-IV, the third most abundant HDL-associated protein, is atheroprotective and shares similar properties as apoA-I. We have reported previously that apoA-I, the most abundant apolipoprotein in HDL, inhibits plaque disruption in a mouse model. We aimed at examining the effects of apoA-IV on markers of plaque stability in vivo.Plaques
F.R.B. Geronimo, P.J. Barter, K.A. Rye, A.K. Heather, K.D. Shearston, K.J. Rodgers   +5 more
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Update in Therapeutic Approaches to Plaque Stabilization

Current Atherosclerosis Reports, 2014
Increasing pathological insights have highlighted the role of plaque instability in the pathogenesis of acute ischemic syndromes. These studies have identified a specific plaque phenotype, characterized by large burden, expansive arterial wall remodeling, and greater composition of lipid, inflammatory, and necrotic material, as the disease most likely ...
Stephen J, Nicholls, Yu, Kataoka
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Carotid Atherosclerotic Plaques Stabilize After Stroke

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— Rupture of unstable atherosclerotic plaques is the pathological substrate for acute ischemic events. Underlying cellular and molecular characteristics of plaque rupture have been studied extensively.
W, Peeters, W E, Hellings, D P V, de Kleijn, J P P M, de Vries, F L, Moll, A, Vink, G, Pasterkamp   +6 more
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Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability

Archives of Biochemistry and Biophysics, 2020
Our previous research revealed that trypsin is abundantly expressed in atherosclerotic plaques and its distribution overlaps with that of matrix metalloproteinase-9 (MMP-9). This study was performed to explore the possible roles of trypsin in vulnerable atherosclerotic plaque formation.Twenty-four rabbits were randomly assigned to a normal (control ...
Jia-Yu, Shi, Hai-Yan, Pan, Kun, Liu, Min, Pan, Guo-Jun, Si   +4 more
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