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Taurine Reduces Atherosclerotic Plaque Area and Stability in Mice
Meng‐Guang Wei +6 more
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European Journal of Cardiovascular Prevention & Rehabilitation, 2003
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are now the standard of care for patients with hypercholesterolaemia. This class of inhibitors, known as 'statins', has been shown to reduce cardiovascular morbidity and mortality. Accumulating data demonstrates a variety of mechanisms in which HMG-CoA reductase inhibition benefits ...
Mardi Gomberg-Maitland +4 more
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3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are now the standard of care for patients with hypercholesterolaemia. This class of inhibitors, known as 'statins', has been shown to reduce cardiovascular morbidity and mortality. Accumulating data demonstrates a variety of mechanisms in which HMG-CoA reductase inhibition benefits ...
Mardi Gomberg-Maitland +4 more
openaire +3 more sources
Mechanisms of plaque stabilization with statins
The American Journal of Cardiology, 2003The traditional view of cardiovascular disease held that the degree of stenosis defined high-risk lesions and that removal of cholesterol shrank these lesions and thereby enlarged the lumen. Advances in understanding of the pathophysiology of the acute coronary syndromes refute this view.
Peter Libby, Masanori Aikawa
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Macrophages and atherosclerotic plaque stability
Current Opinion in Lipidology, 1996Physical disruption of atheroma frequently causes coronary thrombosis. Ruptured plaques usually have thin fibrous caps overlying a large thrombogenic lipid core rich in lipid-laden macrophages. The biology of plaque monocyte-derived macrophages thus assumes critical importance in understanding plaque instability.
Richard T. Lee +7 more
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Plaque Stability and the Southern European Paradox [PDF]
Revista Española de Cardiología (English Edition), 2013 Differences between European countries in coronary heart disease mortality were initially described in the 20th century, and albeit less dramatic than first reported, these differences remain substantial. Three main hypotheses have been proposed to explain the so-called "Mediterranean paradox": a) underestimation of coronary heart disease mortality due
María Grau +5 more
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Atherosclerotic Plaque Stability—What Determines the Fate of a Plaque?
Progress in Cardiovascular Diseases, 2008Although the understanding of the underlying pathology of atherosclerosis has improved in recent years, the disease is still the main cause of death globally. Current evidence has implicated the role of inflammation in atherogenesis and plaque destabilization.
Erik Øie +6 more
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PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION
Cardiology Clinics, 1996Atherosclerotic coronary artery disease is the major cause of death, in men and women, in the United States and in much of the Western world. Atherosclerosis is responsible for coronary heart disease, limb ischemia, and most strokes. Although luminal narrowing by an atherosclerotic plaque and exaggerated or anomalous vasoconstriction contribute to some
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2006
The association between elevated low density lipoprotein (LDL) cholesterol and atherothrombotic vascular disease is well established. Lipid-lowering therapies reduce cardiovascular events; however, the mechanism of benefit attributable to HMG CoA reductase inhibitors likely transcends lipids alone by directly or indirectly affecting inflammatory ...
Richard C. Becker, Frederick A. Spencer
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The association between elevated low density lipoprotein (LDL) cholesterol and atherothrombotic vascular disease is well established. Lipid-lowering therapies reduce cardiovascular events; however, the mechanism of benefit attributable to HMG CoA reductase inhibitors likely transcends lipids alone by directly or indirectly affecting inflammatory ...
Richard C. Becker, Frederick A. Spencer
openaire +1 more source