Results 81 to 90 of about 4,481,490 (243)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Cross-sectional association between plasma aldosterone concentration and cognitive performance by mini-mental state examination in community dwellers

Frontiers in Nutrition
BackgroundAldosterone is the effector hormone in the renin angiotensin aldosterone system and existing data suggest aldosterone affect cognitive function.
Aketilieke Nusufujiang, Mulalibieke Heizhati, Nanfang Li, Ling Yao, Wenbo Yang, Hui Wang, Mei Li, Lin Gan, Adalaiti Maitituersun, Miaomiao Liu, Qiaolifanayi Nuermaimaiti, Li Cai, Xiayire Aierken, Xiufang Li, Qin Luo, Jing Hong   +15 more
doaj   +1 more source

Chronic High‐Salt Intake Reprograms Metabolic Homeostasis Driven by Dietary Rice Varieties via Microbial and Metabolite Associations

iMetaMed, EarlyView.
Using a 2% salt diet and a 10‐month feeding to model chronic human sodium exposure, we found that black rice improved glucose tolerance and short‐chain fatty acids, but 2% salt inverted black rice's blood glucose benefits. White rice + 2% salt treatment uniquely increased short‐chain fatty acids.
Xiaofang Li, Fangyang Chen, Ping Chen, Yage Wang, Mengke Yuan, Zhuojun Li, Hao Chen, Zongkang Zhang, Kaikai Li   +8 more
wiley   +1 more source

Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential hypertension

, 2017
Objective: To investigate the association between aldosterone and cardiac diastolic dysfunction. ;Design and methods: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH).
林彥宏;洪啟盛;吳允升;吳寬墩;陳盈憲;王碩盟, Chang, Yi-Yao;Lee, Hsiu-Hao;Hung, Chi-Sheng;Wu, Xue-Ming;Lee, Jen-Kuang;Wang, Shuo-Meng;Liao, Min-Tsun;Chen, Ying-Hsien;Wu, Vin-Cent;Wu, Kwan-Dun;Lin, Yen-Hung   +1 more
core   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Atrial natriuretic peptide may inhibit motion sickness through reducing aldosterone-induced increase in endolymph volume of the inner ear.

PLoS ONE
Previous studies have suggested that aldosterone is potentially involved in the development of motion sickness and that atrial natriuretic peptide (ANP) may inhibit it.
Qian-Cheng Lu, Wei Ji, Xia Li, Jian-Gang Ge, Li-Hua Xu, Zheng-Lin Jiang   +5 more
doaj   +1 more source

Plasma Steroid Trajectories From Day‐of‐Surgery Baseline After Robot‐Assisted Radical Prostatectomy for Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background Circulating steroid trajectories after robot‐assisted radical prostatectomy are poorly characterized from the day‐of‐surgery baseline, and relevant biology extends beyond testosterone and dihydrotestosterone to adrenal‐derived 11‐oxygenated androgens and steroid conjugate turnover.
Jiri Heracek, Lukas Gadus, Michal Horenitzky, Marie Novakova, Tereza Skodova, Lucie Kolatorova, Anezka Varausova, Adela Lukaskova, Jana Vitku   +8 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells

Scientific Reports, 2017
The typical response to the lowering of plasma Na+ concentration and blood pressure in our body involves the release of aldosterone from the adrenal glands, which triggers the reabsorption of sodium in the kidney.
Leonardo Puppulin, Giuseppe Pezzotti, Hongxin Sun, Shigekuni Hosogi, Takashi Nakahari, Toshio Inui, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Marunaka   +8 more
doaj   +1 more source

Primary aldosteronism: The Mayo Clinic approach

Терапевтический архив, 2020
Primary aldosteronism (PA) is the most common reason of secondary hypertension, that can be cured surgically or treated with targeting medical treatment.
W. Young, D. O. Ladygina, O. V. Balutina, D. G. Beltsevich   +3 more
doaj   +1 more source