Results 141 to 150 of about 636,644 (329)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians

aging and disease
Plasma biomarkers represent promising tools for the screening and diagnosis of patients with neurodegenerative conditions. However, it is crucial to account for the effects of aging on biomarker profiles, especially in the oldest segments of the population.
Gómez-Tortosa, Estrella, Agüero-Rabes, Pablo, Ruiz-González, Alicia, Wagner, Sonia, Téllez, Raquel, Mahillo, Ignacio, Ruiz-Calvo, Andrea, Sainz, María José, Nystrom, Anna Lena, Cremades-Jimeno, Lucía, del Ser, Teodoro, Sánchez-Juan, Pascual   +11 more
openaire   +2 more sources

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

Changes in Faecal Microbiota Profile and Plasma Biomarkers following the Administration of an Antioxidant Oleuropein-Rich Leaf Extract in a Rat Model Mimicking Colorectal Cancer

Antioxidants
Oleuropein (OLE), a phenolic compound particularly abundant in the olive leaves, has been reported to have beneficial activities against colorectal cancer (CRC).
Sofia Chioccioli, Gabriele Rocchetti, Jessica Ruzzolini, Silvia Urciuoli, Francesco Vitali, Gianluca Bartolucci, Marco Pallecchi, Giovanna Caderni, Carlotta De Filippo, Chiara Nediani, Luigi Lucini   +10 more
doaj   +1 more source

Perinatal mood and anxiety disorders: biomarker discovery using plasma proteomics [PDF]

, 2023
Eynav Elgavish Accortt, James Mirocha, Dongsheng Zhang, Sarah J. Kilpatrick, Towia A. Libermann, S. Ananth Karumanchi   +5 more
openalex   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Plasma miRNA expression profile in pediatric pineal pure germinomas

Frontiers in Oncology
BackgroundPure germinomas account for 40% of pineal tumors and are characterized by the lack of appreciable tumor markers, thus requiring a tumor biopsy for diagnosis.
Mona Fakhry, Moatasem Elayadi, Moatasem Elayadi, Mariam G. Elzayat, Omar Samir, Eslam Maher, Hala Taha, Mohamed El-Beltagy, Amal Refaat, Manal Zamzam, Manal Zamzam, Mohamed S. Abdelbaki, Ahmed A. Sayed, Ahmed A. Sayed, Mark Kieran, Alaa Elhaddad   +15 more
doaj   +1 more source

[Retracted] MicroRNA‐340 and MicroRNA‐450b‐5p: Plasma Biomarkers for Detection of Non‐Small‐Cell Lung Cancer [PDF]

, 2022
Yanmin Wu, Hui Jing, Jinghao Zhang
openalex   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source