Results 151 to 160 of about 636,644 (329)

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Associations between amyloid‐tau‐neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D).
Luciana Mascarenhas Fonseca, Michal Schnaider Beeri, Zoë W. Hawks, Lanee Jung, Michael Cleveland, Nikki Delgado, Jane Bulger, Elizabeth Grinspoon, Kamille Janess, Martin J. Sliwinski, Ruth S. Weinstock, Jasmeer P. Chhatwal, Pia Kivisäkk, Laura Thi Germine, Naomi S. Chaytor   +14 more
doaj   +1 more source

Discovery of plasma biomarkers related to blood-brain barrier dysregulation in Alzheimer’s disease

Frontiers in Bioinformatics
IntroductionBlood-based biomarkers are quantitative, non-invasive diagnostic tools. This study aimed to identify candidate biomarkers for Alzheimer’s disease (AD) using publicly available omics datasets, using the hypothesis that with blood-brain barrier
Yuet Ruh Dan, Yuet Ruh Dan, Keng-Hwee Chiam, Keng-Hwee Chiam   +3 more
doaj   +1 more source

Protein profiling in plasma for biomarkers of seizure

, 2023
Sarah Akel, Rakesh Kumar Banote, Fredrik Asztély, Johan Zelano   +3 more
openalex   +1 more source

Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker‐guided diagnostics

Alzheimer's & Dementia
AbstractINTRODUCTIONThis study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD).METHODSA total of 2984 participants, including 666 cognitively unimpaired (CU), 2032 with Alzheimer's clinical syndrome (ACS), and 286 non‐ACS individuals, were recruited.
Jang, Hyemin, Shin, Daeun, Yoo, Heejin, Zetterberg, Henrik, Blennow, Kaj, Gonzalez‐Ortiz, Fernando, Ashton, Nicholas J., Day, Theresa A., Lee, Eun Hye, Yun, Jihwan, Na, Duk L, Kim, Hee Jin, Kang, Sung Hoon, Kim, Ko Woon, Kim, Si Eun, Kim, Yeo Jin, Kim, Yeshin, Kim, Jaeho, Kim, Chi‐Hun, Chun, Min Young, Jung, Na Yeon, Cho, Soo Hyun, Kim, Jun Pyo, Seo, Sang Won   +23 more
openaire   +2 more sources

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Biomarkers of Neurodegeneration and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study

Endocrines
Adult-onset diabetes increases one’s risk of neurodegenerative disease including Alzheimer’s disease (AD); however, the risk associated with youth-onset diabetes (Y-DM) remains underexplored. We quantified plasma biomarkers of neurodegeneration and AD in
Allison L. B. Shapiro, Christina Coughlan, Brianne M. Bettcher, Meghan E. Pauley, Jeongchul Kim, Petter Bjornstad, Benjamin Rajic, Jennifer Truong, Christopher Bell, Ye Ji Choi, Keenan A. Walker, Huntington Potter, Angela D. Liese, Dana Dabelea, Christopher T. Whitlow   +14 more
doaj   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Screening of miRNAs in plasma as a diagnostic biomarker for cardiac disease based on optimization of extraction and qRT-PCR condition assay through amplification efficiency [PDF]

, 2021
Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo, Eun Joo Song   +4 more
openalex   +1 more source