Results 311 to 320 of about 636,644 (329)

Relevance of plasma biomarkers to imaging biomarkers

Alzheimer's & Dementia, 2023
AbstractBackgroundRecent advances in blood‐based biomarkers have shown promising abilities to estimate brain pathological statuses related to amyloid‐β (Aβ) deposition, phosphorylated tau deposition, and neurodegeneration using minimally invasive methods.
Akinori Nakamura, Takahiko Tokuda, Naoki Kaneko, Takashi Kato, Harutsugu Tatebe, Takashi Nihashi, Keita Sakurai, Akinori Takeda, Yutaka Arahata, Kengo Ito   +9 more
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Genetic architecture of plasma Alzheimer’s disease biomarkers

Alzheimer's & Dementia, 2023
AbstractBackgroundCase‐control genome‐wide association studies (GWAS) have identified loci associated with risk for Alzheimer disease (AD), but they require very large sample sizes and identify variants with small effect sizes. GWAS of informative endophenotypes for disease have more power to identify novel variants and provide information about ...
Joseph Bradley, Priyanka Gorijala, Suzanne E Schindler, Yun J Sung, Beau Ances, Nilüfer Ertekin-Taner, Steven Younkin, Todd Golde, Nathan Price, David Bennett, Christopher Gaiteri, Philip De Jager, Bin Zhang, Eric Schadt, Michelle Ehrlich, Vahram Haroutunian, Sam Gandy, Koichi Iijima, Scott Noggle, Lara Mangravite, Maria V Fernandez, Carlos Cruchaga   +21 more
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Plasma biomarkers of Alzheimer's disease

Current Opinion in Psychiatry, 2008
The importance of biomarkers of Alzheimer's disease is increasing. The present review aims to offer a general view of plasma biomarkers of Alzheimer's disease and to discuss their relevance and limitations.The broad overlap in the plasma amyloid beta protein (Abeta) levels between patients with Alzheimer's disease and control individuals indicates that
Takeshi, Kawarabayashi, Mikio, Shoji
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On the Development of Plasma Protein Biomarkers

Journal of Proteome Research, 2011
The development of plasma biomarkers has proven to be more challenging than initially anticipated. Many studies have reported lists of candidate proteins rather than validated candidate markers with an assigned performance to a specific clinical objective.
Surinova Silvia, Schiess Ralph, Hüttenhain Ruth, Cerciello Ferdinando, Wollscheid Bernd, Aebersold Ruedi   +5 more
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Plasma biomarkers for Alzheimer’s

C&EN Global Enterprise, 2018
Protein clumps called amyloids accumulate in the brains of people with Alzheimer’s disease. The current methods for detecting amyloids—positron emission tomography (PET) imaging of the brain and measurement of the clumping protein amyloid-β in cerebrospinal fluid—are expensive and invasive.
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Mining the plasma proteome for cancer biomarkers

Nature, 2008
Systematic searches for plasma proteins that are biological indicators, or biomarkers, for cancer are underway. The difficulties caused by the complexity of biological-fluid proteomes and tissue proteomes (which contribute proteins to plasma) and by the extensive heterogeneity among diseases, subjects and levels of sample procurement are gradually ...
Samir M, Hanash, Sharon J, Pitteri, Vitor M, Faca   +2 more
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Potential Alzheimer's Disease Plasma Biomarkers

2023
In this series of studies, we examined the potential of a variety of blood-based plasma biomarkers for the identification of Alzheimer's disease (AD) progression and cognitive decline. With the end goal of studying these biomarkers via mixture modeling, we began with a literature review of the methodology.
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Placenta Accreta Spectrum: Biomarker Discovery Using Plasma Proteomics

Obstetric Anesthesia Digest, 2020
(Am J Obstet Gynecol. 2020;223:433.e1–14) Placenta accreta spectrum (PAS), which includes placenta accreta, placenta increta and placenta percreta, often leads to hysterectomy and large-volume maternal hemorrhage and is a major cause of maternal mortality and morbidity.
Scott A, Shainker, Robert M, Silver, Anna M, Modest, Michele R, Hacker, Jonathan L, Hecht, Saira, Salahuddin, Simon T, Dillon, Erin J, Ciampa, Mary E, D'Alton, Hasan H, Otu, Alfred Z, Abuhamad, Brett D, Einerson, D Ware, Branch, Blair J, Wylie, Towia A, Libermann, S Ananth, Karumanchi   +15 more
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iTRAQ Experimental Design for Plasma Biomarker Discovery

Journal of Proteome Research, 2008
There is considerable interest in using mass spectrometry for biomarker discovery in human blood plasma. We investigated aspects of experimental design for large studies that require analysis of multiple sample sets using iTRAQ reagents for sample multiplexing and quantitation.
Xiaomin, Song, Julia, Bandow, Jamie, Sherman, J David, Baker, Paul W, Brown, Michael T, McDowell, Mark P, Molloy   +6 more
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Plasma metabolomics reveals biomarkers of the atherosclerosis

Journal of Separation Science, 2010
AbstractAtherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in industrialized societies. The lack of metabolite biomarkers has impeded the clinical diagnosis of atherosclerosis so far. In this study, stable atherosclerosis patients (n=16) and age‐ and sex‐matched non‐atherosclerosis healthy subjects (n=28) were ...
Chen, Xi, Liu, Lian, Palacios, Gustavo, Gao, Jie, Zhang, Ning, Li, Guang, Lu, Juan, Song, Ting, Zhang, Yingzhi, Lu, Haitao   +9 more
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