Results 81 to 90 of about 2,773,444 (301)

Thrice weekly nocturnal in-centre haemodiafiltration: a 2-year experience [PDF]

, 2015
Background: Adequate control of plasma phosphate without phosphate binders is difficult to achieve on a thrice-weekly haemodialysis schedule. The use of quotidian nocturnal dialysis is effective but not practical in the in-centre setting.
Dey, V., Hair, M., Spalding, E. M.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Statistical features of edge turbulence in RFX-mod from Gas Puffing Imaging [PDF]

, 2006
Plasma density fluctuations in the edge plasma of the RFX-mod device are measured through the Gas Puffing Imaging Diagnostics. Statistical features of the signal are quantified in terms of the Probability Distribution Function (PDF), and computed for ...
Antoni V, Bodin H A B, Carraro L, Cavazzana R, Escande D F, F Sattin, G Serianni, Garcia O E, Graves J P, Jakeman E, Jaynes E T, Kirnev G S, LaBombard B, M Agostini, M Spolaore, Martin P, N Vianello, P Scarin, Paccagnella R, Puiatti M E, R Cavazzana, Rudakov D L, Scarin P, Xu Y H, Zanca P   +24 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Demonstration of reconstruction-free static magnetic control of DIII-D plasma with deep reinforcement learning

Nuclear Fusion
This paper presents the development and experimental validation of a reinforcement learning (RL)-based magnetic controller on the DIII-D tokamak. The controller directly maps raw magnetic diagnostic signals to actuator commands, replacing the traditional
G.F. Subbotin, D.I. Sorokin, M.R. Nurgaliev, A.A. Granovskiy, I.P. Kharitonov, E.V. Adishchev, E.N. Khairutdinov, R. Clark, H. Shen, W. Choi, J. Barr, D.M. Orlov   +11 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optical coherence tomography with enhanced contrast using oriented magnetic nanorods [PDF]

Frontiers of Optoelectronics
In recent years, the utilization of nanoparticles with varying morphologies in optical coherence tomography (OCT) has gained prominence, primarily aimed at enhancing imaging contrast and depth.
Seyyede Sarvenaz Khatami, Mohammad Ali Ansari, Behnam Shariati Bein Kalaee, Valery V. Tuchin   +3 more
doaj   +1 more source

Pressure anisotropy generation in a magnetized plasma configuration with a shear flow velocity

, 2015
The nonlinear evolution of the Kelvin Helmholtz instability in a magnetized plasma with a perpendicular flow close to, or in, the supermagnetosonic regime can produce a significant parallel-to-perpendicular pressure anisotropy. This anisotropy, localized
Califano, F., Cerri, S. S., De Camillis, S., Pegoraro, F.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Review of the application of plasma technology in air pollution control [PDF]

طب کار, 2023
Background and Objective: Plasma is considered as the fourth state of matter. Non-thermal plasma is more popular due to its unique features such as easy operation, quick reaction at ambient temperature and short residence time.
zahra ordudari, masoud rismanchian
doaj