Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Collective Effects: the viewpoint of HEP MC codes
, 2018 Collective effects are observed in high-multiplicity pp events, similar to the signals traditionally attributed to the formation of a Quark Gluon Plasma in heavy ion collisions.
Sjöstrand, Torbjörn
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Retraction: Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device. [PDF]
PLoS One, 2023 PLOS ONE Editors.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Sn/Pb ratio variation in spherical structures deposited on silicon surface using plasma focus. [PDF]
Heliyon, 2023 Ahmad M, Akel M, Al-Hawat S.
europepmc +1 more source
LE PLASMA FOCUS : INTERACTION PLASMA-COURANT ET PHÉNOMÈNES COLLECTIFS
Le Journal de Physique Colloques, 1978 Les phénomènes principaux de l'expérience Focus sont dûs à l'interaction d'une décharge de courant intense avec le plasma quand sont remplies les conditions de développement des instabilités microscopiques. On observe des fluctuations de densité suprathermiques, l'accélération de faisceaux d'électrons et d'ions à de hautes énergies et une résistivité ...
Bernard, A. +5 more
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Bayesian inference of spectrometric data and validation with numerical simulations of plasma sheath diagnostics of a plasma focus discharge. [PDF]
Sci Rep, 2022 Avaria G +8 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source