Results 51 to 60 of about 5,745,214 (212)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Experimental Investigations of Magnetohydrodynamic Plasma Jets [PDF]

open access: yes, 2009
This thesis primarily focuses on understanding the plasma behavior during the helicity injection stage of a pulsed spheromak experiment. Spheromak formation consists of a series of dynamic steps whereby highly localized plasma near the electrodes evolves
Kumar, Deepak
core   +1 more source

Estimation of Amount of Scattered Neutrons at Devices PFZ and GIT-12 by MCNP Simulations

open access: yesActa Polytechnica, 2013
Our work is dedicated to pinch effect occurring during current discharge in deuterium plasma, and our results are connected with two devices – plasma focus PFZ, situated in the Faculty of Electrical Engineering, CTU, Prague, and Z-pinch GIT-12, which is ...
Ondrej Šíla   +5 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Final focus system for injection into a laser plasma accelerator

open access: yesPhysical Review Accelerators and Beams, 2021
ARES is an electron linear accelerator at the SINBAD facility at DESY. It aims to deliver reliable high-brightness beams with an energy in the range of 100 to 150 MeV with fs to sub-fs bunch lengths.
S. Yamin   +7 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Evolution of the small ball-like structures in the plasma focus discharge

open access: yesNukleonika, 2016
The experiments were carried out in the PF-1000 plasma-focus device at the maximum current reaching about 2 MA, at the deuterium or neon filling and with deuterium injected from a gas-puff nozzle placed on the axis of the anode face. Ball-like structures
Cikhardtova Balzhima   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Focus Ireland annual report 1999.

open access: yes, 2000
Focus Ireland believes that everyone has the right to a place they can call home and to live a life with dignity at an acceptable standard of living. Sadly, however, this is not always the case for many people in Ireland despite the sometimes seemingly
Focus Ireland
core  

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