Results 141 to 150 of about 2,752,610 (400)

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression

Advanced Science, EarlyView.
Migrasomes play a crucial role in endothelial‐immune interactions in atherosclerosis. This study identifies migrasomes as amplifiers in the inflammatory cascade, driving immune‐metabolic reprogramming via “migrasome‐APP‐CD74” signaling. Blocking CD74 disrupts migrasome‐mediated signaling, attenuating atherosclerosis progression.
Kangnan Zhang, Jiong Chen, Zhenhua Zhu, Hong Hu, Qinghui Zhang, Rongrong Jia, Na Wang, Shihao Xiang, Yong Zhou, Yuehong Wang, Ling Xu   +10 more
wiley   +1 more source

Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia.

Journal of Lipid Research, 1992
Hyperlipidemia is a prominent feature of the nephrotic syndrome. Lipoprotein abnormalities include increased very low and low density lipoprotein (VLDL and LDL) cholesterol and variable reductions in high density lipoprotein (HDL) cholesterol.
P Moulin, GB Appel, HN Ginsberg, AR Tall
doaj  

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Effect of fasting on the composition of plasma lipoproteins in cholesterol-fed diabetic rabbits.

Journal of Lipid Research, 1985
Cholesterol-fat feeding is associated with unusual alterations in the composition of plasma lipoproteins in alloxan-diabetic rabbits. In the present study plasma lipoprotein lipid and apoprotein composition was studied before and after 48 hr of fasting ...
W A Van Sickle, P Brecher, A Aspen, A V Chobanian   +3 more
doaj  

Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. [PDF]

J Clin Invest, 2022
Izquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus N, Camastra S, Unterman TG, Ferrannini E, Hurwitz BE, Haeusler RA.   +17 more
europepmc   +1 more source

Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins

Advanced Science, EarlyView.
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard, Rikke Fabech Hansson, Mikkel Høj Nielsen, Alexander N. Zelikin   +3 more
wiley   +1 more source

Hyperlipoproteinemia in Nagase analbuminemic rats: effects of pravastatin on plasma (apo)lipoproteins and lecithin:cholesterol acyltransferase activity.

Journal of Lipid Research, 1991
The present study demonstrates very high levels of plasma lipids and high density lipoprotein (HDL) apolipoproteins (apoA-I and apoE) in female Nagase analbuminemic rats (NAR) fed a semi-synthetic diet in order to further increase the hyperlipidemia ...
A Van Tol, EH Jansen, HA Koomans, JA Joles   +3 more
doaj  

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease. [PDF]

Biomedicines, 2021
Bonaterra-Pastra A, Fernández-de-Retana S, Rivas-Urbina A, Puig N, Benítez S, Pancorbo O, Rodríguez-Luna D, Pujadas F, Freijo MDM, Tur S, Martínez-Zabaleta M, Cardona Portela P, Vera R, Lebrato-Hernández L, Arenillas JF, Pérez-Sánchez S, Montaner J, Sánchez-Quesada JL, Hernández-Guillamon M.   +18 more
europepmc   +1 more source

Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail‐Eating Snake

Advanced Science, EarlyView.
Dietary adaptation studies from a holobiome perspective are scarce beyond mammals. This research reveals how genomic and microbial interactions drive dietary specialization in the Mengla snail‐eating snake, with evidence of gut symbiont convergence between reptiles and mammals.
Chaochao Yan, Xin‐Ning Li, Zhong‐Liang Peng, Wei Wu, Zeng Wang, Zhao‐Ran Zhu, Jia‐Chang Liu, Yao Wang, Jin‐Long Ren, Zhi‐Yi Zhang, Jia‐Tang Li   +10 more
wiley   +1 more source