Results 201 to 210 of about 1,082,753 (262)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane. [PDF]

Sci Adv
Sil P, van Zanten TS, Jahnavi S, Bansal A, Razmazma H, Saha S, Mahajan B, Kumar M, Stansfeld PJ, Singh PP, Rao M, Mayor S.   +11 more
europepmc   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Clustering hinders APP α-secretase processing in the plasma membrane. [PDF]

Biophys J
Pinkwart K, Lang T.
europepmc   +1 more source

The Plasma Membrane

CYTOLOGIA, 1934
openaire   +2 more sources

Pulsed Oxidative–Reductive Electrolysis Over Dual Cu and Co Single‐Atom Sites for Urea Electrosynthesis

Advanced Materials, EarlyView.
Alternating oxidative–reductive pulses synchronize CO2‐derived *CO and NH3‐derived *NHx intermediates over dual Cu and Co single‐atom sites, enabling urea and ethyl urea formation with a total C─N Faradaic efficiency of 42 ± 4%. In situ spectroscopy and theoretical calculations elucidate complementary Cu and Co functions, while oxidative controls ...
Putri Ramadhany, Peiqi Qiu, Thành Trần‐Phú, Denny Gunawan, Bernt Johannessen, Rosalie K. Hocking, Yan Jiao, Rose Amal, Rahman Daiyan   +8 more
wiley   +1 more source

Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm. [PDF]

Microb Cell
Rivera-Palomino GO, Theiss AL.
europepmc   +1 more source

ATG9A-mediated plasma membrane repair is linked to Vps13A and regulated by glycosylation. [PDF]

Proc Natl Acad Sci U S A
Muskat NH, Nevo-Yassaf I, Chaurasia M, Reiss S, Goliand I, Kupervaser M, Addadi Y, Levin Y, Fraiberg M, Elazar Z.   +9 more
europepmc   +1 more source

CROP2, a Retriever-PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells. [PDF]

Elife
De Leo MG, Mayer A.
europepmc   +1 more source

<i>ag85A</i> loss promotes free mycolate accumulation and sensitizes plasma membrane domain to disruption. [PDF]

J Bacteriol
Kado T, Shivangi, Bosworth PH, Jordan J, Freundlich JS, Siegrist MS, Morita YS.   +6 more
europepmc   +1 more source