Results 1 to 10 of about 315,200 (280)
The septin cytoskeleton is required for plasma membrane repair [PDF]
EMBO Reports, 2023 Plasma membrane repair is a fundamental homeostatic process of eukaryotic cells. Here, we report a new function for the conserved cytoskeletal proteins known as septins in the repair of cells perforated by pore-forming toxins or mechanical disruption ...
M Isabella Prislusky +9 more
doaj +6 more sources
Cellular mechanisms and signals that coordinate plasma membrane repair [PDF]
Cellular and Molecular Life Sciences, 2018 Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired.
Adam Horn, Jyoti K Jaiswal
exaly +4 more sources
Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases [PDF]
Cells, 2023 Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases.
Hannah R. Bulgart +2 more
doaj +4 more sources
Structural and signaling role of lipids in plasma membrane repair [PDF]
Current Topics in Membranes, 2019 The plasma membrane forms the physical barrier between the cytoplasm and extracellular space, allowing for biochemical reactions necessary for life to occur. Plasma membrane damage needs to be rapidly repaired to avoid cell death. This relies upon the coordinated action of the machinery that polarizes the repair response to the site of injury ...
Adam Horn, Jyoti K Jaiswal
exaly +4 more sources
Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells
Bio-Protocol, 2022 Damage to the plasma membrane and loss of membrane integrity are detrimental to eukaryotic cells. It is, therefore, essential that cells possess an efficient membrane repair system to survive.
Stine Sønder +4 more
doaj +4 more sources
Cell Reports, 2020 Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu +16 more
doaj +3 more sources
Cells, 2020 The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix +16 more
doaj +3 more sources
High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair
Frontiers in Cellular and Infection Microbiology, 2017 The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis
Sarika Pathak-Sharma +6 more
doaj +3 more sources
Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore [PDF]
Biology Open, 2018 Endocytic mechanisms have been suggested to be important for plasma membrane repair in response to pore-forming toxins such as listeriolysin O (LLO), which form membrane pores that disrupt cellular homeostasis.
Lars Nygård Skalman +3 more
doaj +4 more sources
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins [PDF]
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
doaj +5 more sources