Results 1 to 10 of about 3,013,542 (232)
The septin cytoskeleton is required for plasma membrane repair
EMBO Reports, 2023 Plasma membrane repair is a fundamental homeostatic process of eukaryotic cells. Here, we report a new function for the conserved cytoskeletal proteins known as septins in the repair of cells perforated by pore-forming toxins or mechanical disruption ...
M Isabella Prislusky +9 more
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Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells
Bio-Protocol, 2022 Damage to the plasma membrane and loss of membrane integrity are detrimental to eukaryotic cells. It is, therefore, essential that cells possess an efficient membrane repair system to survive.
Stine Sønder +4 more
doaj +5 more sources
Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair [PDF]
Cells, 2020 The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix +16 more
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High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis
Sarika Pathak-Sharma +6 more
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Annexin A2 Mediates Dysferlin Accumulation and Muscle Cell Membrane Repair
Cells, 2020 Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal ...
Daniel C. Bittel +7 more
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Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair [PDF]
eLife, 2023 Exosomes are an extracellular vesicle (EV) subtype that is secreted upon the fusion of multivesicular bodies (MVBs) with the plasma membrane. Exosomes may participate in intercellular communication and have utility as disease biomarkers; however, little ...
Justin Krish Williams +3 more
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Cell Reports, 2020 Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu +16 more
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Plasma membrane integrity: implications for health and disease [PDF]
BMC Biology, 2021 Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment.
Dustin A. Ammendolia +2 more
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Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
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Lectin-based food poisoning: a new mechanism of protein toxicity. [PDF]
PLoS ONE, 2007 BACKGROUND: Ingestion of the lectins present in certain improperly cooked vegetables can result in acute GI tract distress, but the mechanism of toxicity is unknown.
Katsuya Miyake +2 more
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