Results 21 to 30 of about 173,214 (234)
Plasma membrane repair empowers the necrotic survivors as innate immune modulators [PDF]
Seminars in Cell and Developmental BiologySuhong Xu, Yi-Nan Gong
exaly +2 more sources
Annexin A2 Mediates Dysferlin Accumulation and Muscle Cell Membrane Repair
Cells, 2020 Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal ...
Daniel C. Bittel +7 more
doaj +1 more source
Plasma membrane integrity: implications for health and disease
BMC Biology, 2021 Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment.
Dustin A. Ammendolia +2 more
doaj +1 more source
An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery
Pharmaceutics, 2022 Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease.
Stephanie He +2 more
doaj +1 more source
Shape of the membrane neck around a hole during plasma membrane repair. [PDF]
Biophys JPlasma membrane damage and rupture occurs frequently in cells, and holes must be sealed rapidly to ensure homeostasis and cell survival. The membrane repair machinery is known to involve recruitment of curvature-inducing annexin proteins, but the connection between membrane remodeling and hole closure is poorly described.
Klenow MB +5 more
europepmc +4 more sources
Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential
Cells, 2022 The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li +6 more
doaj +1 more source
iScience, 2021 Summary: The plasma membrane repair holds significance for maintaining cell survival and homeostasis. To achieve the sensitive visualization of membrane repair process for revealing its mechanism, this work designs a perforation-induced surface-enhanced ...
Yuanjiao Yang +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 After damage, cells repair their plasma membrane in an active process that is driven by Ca2+ entering through the wound. This triggers a range of Ca2+-regulated events such as the translocation of different Ca2+-binding proteins to the wound site which ...
Arsila P. K. Ashraf, Volker Gerke
doaj +1 more source
The antioxidant requirement for plasma membrane repair in skeletal muscle. [PDF]
Free Radic Biol Med, 2015 Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of the pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal
Labazi M +7 more
europepmc +5 more sources
Damage control: cellular mechanisms of plasma membrane repair. [PDF]
Trends Cell Biol, 2014 When wounded, eukaryotic cells reseal in a few seconds. Ca(2+) influx induces exocytosis of lysosomes, a process previously thought to promote repair by 'patching' wounds. New evidence suggests that resealing involves direct wound removal. Exocytosis of lysosomal acid sphingomyelinase (ASM) triggers endocytosis of lesions followed by intracellular ...
Andrews NW, Almeida PE, Corrotte M.
europepmc +4 more sources