Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
Cells, 2023 Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases.
Hannah R. Bulgart +2 more
doaj +4 more sources
Dealing with damage: Plasma membrane repair mechanisms [PDF]
Biochimie, 2014 Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual function: it provides guidance cues for the repair machinery and directly activates the molecules ...
Draeger, Annette +4 more
core +5 more sources
Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. [PDF]
PLoS ONE, 2016 Eukaryotic cells rapidly repair wounds on their plasma membrane. Resealing is Ca(2+)-dependent, and involves exocytosis of lysosomes followed by massive endocytosis.
Thiago Castro-Gomes +3 more
doaj +2 more sources
The antioxidant requirement for plasma membrane repair in skeletal muscle [PDF]
Free Radical Biology and Medicine, 2015 Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of the pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal
Labazi, M. +7 more
openaire +4 more sources
Timescale of hole closure during plasma membrane repair estimated by calcium imaging and numerical modeling [PDF]
Scientific Reports, 2021 Plasma membrane repair is essential for eukaryotic cell life and is triggered by the influx of calcium through membrane wounds. Repair consists of sequential steps, with closure of the membrane hole being the key event that allows the cell to recover ...
Martin Berg Klenow +3 more
doaj +2 more sources
Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore [PDF]
Biology Open, 2018 Endocytic mechanisms have been suggested to be important for plasma membrane repair in response to pore-forming toxins such as listeriolysin O (LLO), which form membrane pores that disrupt cellular homeostasis.
Lars Nygård Skalman +3 more
doaj +4 more sources
Current Biology, 2018 Tissue wound repair has been studied extensively. It involves the coordinated activation of several intracellular and intercellular pathways, as well as remodeling from the sequential recruitment of different cell types to the wound site. There is, however, an equally important process that happens at the single cell level, when the integrity of the ...
Norma W, Andrews, Matthias, Corrotte
openaire +2 more sources
An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery
Pharmaceutics, 2022 Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease.
Stephanie He +2 more
doaj +1 more source
Clathrin-mediated trafficking of phospholipid flippases is required for local plasma membrane/cell wall damage repair in budding yeast [PDF]
, 2022 Plasma membrane damage and repair frequently happen in cells. A critical process underlying plasma membrane repair is to redirect repair factors, such as protein kinase C and the exocyst complex, from the polarized site to the damage site.
Yamazaki, Yuta, Kono, Keiko
core +2 more sources
Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential
Cells, 2022 The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li +6 more
doaj +1 more source