Results 11 to 20 of about 315,200 (280)

Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair [PDF]

eLife, 2023
Exosomes are an extracellular vesicle (EV) subtype that is secreted upon the fusion of multivesicular bodies (MVBs) with the plasma membrane. Exosomes may participate in intercellular communication and have utility as disease biomarkers; however, little ...
Justin Krish Williams, Jordan Matthew Ngo, Isabelle Madeline Lehman, Randy Schekman   +3 more
doaj   +2 more sources

Timescale of hole closure during plasma membrane repair estimated by calcium imaging and numerical modeling [PDF]

Scientific Reports, 2021
Plasma membrane repair is essential for eukaryotic cell life and is triggered by the influx of calcium through membrane wounds. Repair consists of sequential steps, with closure of the membrane hole being the key event that allows the cell to recover ...
Martin Berg Klenow, Anne Sofie Busk Heitmann, Jesper Nylandsted, Adam Cohen Simonsen   +3 more
doaj   +2 more sources

Plasma Membrane Repair in Health and Disease [PDF]

Curr Top Membr, 2016
Since an intact membrane is required for normal cellular homeostasis, membrane repair is essential for cell survival. Human genetic studies, combined with the development of novel animal models and refinement of techniques to study cellular injury, have now uncovered series of repair proteins highly relevant for human health.
Alexis R, Demonbreun, Elizabeth M, McNally   +1 more
openaire   +3 more sources

Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. [PDF]

PLoS ONE, 2016
Eukaryotic cells rapidly repair wounds on their plasma membrane. Resealing is Ca(2+)-dependent, and involves exocytosis of lysosomes followed by massive endocytosis.
Thiago Castro-Gomes, Matthias Corrotte, Christina Tam, Norma W Andrews   +3 more
doaj   +2 more sources

Damage control: cellular mechanisms of plasma membrane repair [PDF]

Trends in Cell Biology, 2014
When wounded, eukaryotic cells reseal in a few seconds. Ca(2+) influx induces exocytosis of lysosomes, a process previously thought to promote repair by 'patching' wounds. New evidence suggests that resealing involves direct wound removal. Exocytosis of lysosomal acid sphingomyelinase (ASM) triggers endocytosis of lesions followed by intracellular ...
Norma W, Andrews, Patricia E, Almeida, Matthias, Corrotte   +2 more
openaire   +3 more sources

The antioxidant requirement for plasma membrane repair in skeletal muscle [PDF]

Free Radical Biology and Medicine, 2015
Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of the pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal
Labazi, M., McNeil, A.K., Kurtz, T., Lee, T.C., Pegg, R.B., Friedmann Angeli, J.P.F., Conrad, M., McNeil, P.L.   +7 more
openaire   +4 more sources

Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery [PDF]

Cell Regeneration
Cells can recover from sub-lethal necrosis by repairing plasma-membrane (PM) rupture through the ESCRT-III machinery, but how this process is regulated remains unknown. Here, we identify Toll-interacting protein (Tollip) as a conserved negative regulator
Julia M. Ferrick, Xinan Meng, Emily Morgan, Anthony Kalvi, Zhen Li, Chaoqun Li, Chao-Yuan Chang, Suhong Xu, Yi-Nan Gong   +8 more
doaj   +2 more sources

Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair

PLoS Currents, 2015
Dysferlin is a sarcolemmal protein that is defective in Miyoshi myopathy and limb-girdle muscular dystrophy type 2B, and is involved in sarcolemmal repair. Primary cultured myoblasts and myotubes established from patient muscle biopsies have been widely utilized to explore the molecular mechanism of dysferlinopathy.The purpose of this study was to ...
Matsuda, Chie, Kiyosue, Kazuyuki, Nishino, Ichizo, Goto, Yuichi, Hayashi, Yukiko K.   +4 more
openaire   +3 more sources

Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage [PDF]

eLife
Damage to the plasma membrane (PM) is common in all types of cells. PM repair processes, including exocytosis and endocytosis, are not mutually exclusive; rather, they collaborate to repair the wound. However, the temporal coordination between the repair
Yuta Yamazaki, Keiko Kono
doaj   +2 more sources

Plasma Membrane Repair Is Mediated by Ca2+-Regulated Exocytosis of Lysosomes [PDF]

Cell, 2001
Plasma membrane wounds are repaired by a mechanism involving Ca(2+)-regulated exocytosis. Elevation in intracellular [Ca(2+)] triggers fusion of lysosomes with the plasma membrane, a process regulated by the lysosomal synaptotagmin isoform Syt VII. Here, we show that Ca(2+)-regulated exocytosis of lysosomes is required for the repair of plasma membrane
Norma W Andrews
exaly   +3 more sources