Results 41 to 50 of about 3,013,542 (232)
Into the breach: how cells cope with wounds [PDF]
Open Biology, 2018 Repair of wounds to individual cells is crucial for organisms to survive daily physiological or environmental stresses, as well as pathogen assaults, which disrupt the plasma membrane.
Mitsutoshi Nakamura +5 more
doaj +1 more source
Defective membrane repair machinery impairs survival of invasive cancer cells
Scientific Reports, 2020 Cancer cells are able to reach distant tissues by migration and invasion processes. Enhanced ability to cope with physical stresses leading to cell membrane damages may offer to cancer cells high survival rate during metastasis.
F. Bouvet +7 more
doaj +1 more source
Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair
PLoS Currents, 2015 Dysferlin is a sarcolemmal protein that is defective in Miyoshi myopathy and limb-girdle muscular dystrophy type 2B, and is involved in sarcolemmal repair. Primary cultured myoblasts and myotubes established from patient muscle biopsies have been widely utilized to explore the molecular mechanism of dysferlinopathy.The purpose of this study was to ...
Matsuda, Chie +4 more
openaire +2 more sources
The SNARE complex formed by RIC-4/SEC-22/SYX-2 promotes C. elegans epidermal wound healing
Cell Reports, 2023 Summary: Maintaining cellular viability relies on the integrity of the plasma membrane, which must be repaired upon damage. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is a crucial mechanism ...
Qingfang Shao +6 more
doaj +1 more source
Phosphatidylserine Regulates Plasma Membrane Repair through Tetraspanin-Enriched Macrodomains [PDF]
The integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes.
Du, Guangwei +10 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Recruitment of tetraspanin TSP-15 regulates plasma membrane repair in C. elegans epidermis
, 2023 Maintaining the integrity of the plasma membrane after cellular damage is essential for cell survival. However, it is unclear how cells repair large membrane injuries in vivo. In this study, we report that the tetraspanin protein, TSP-15, is recruited to
Xu, S (via Mendeley Data), Xu, Suhong
core +2 more sources
Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis [PDF]
The Journal of Cell Biology, 2008 Ca2+ influx through plasma membrane lesions triggers a rapid repair process that was previously shown to require the exocytosis of lysosomal organelles (Reddy, A., E. Caler, and N. Andrews. 2001. Cell. 106:157–169). However, how exocytosis leads to membrane resealing has remained obscure, particularly for stable lesions caused by pore-forming proteins.
Idone, Vincent +5 more
openaire +2 more sources
Studies on muscular dystrophy associated genes [PDF]
, 2007 Muscular dystrophy is a collective group of genetic disorder that results in progressive wasting of skeletal muscle. Dysferlin, the gene responsible for Limb Girdle Muscular Dystrophy type 2B (LGMD2B) and Miyoshi Myopathy (MM) was found to be a member of
Bakir, Hadil
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source