Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]
, 2018 The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda +64 more
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Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible [PDF]
, 2008 The aminophospholipid phosphatidylserine (PS) is normally restricted to the inner leaflet of the plasma membrane. During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied ...
Gale, Jonathan E +4 more
core +1 more source
Promotion of plasma membrane repair by vitamin E [PDF]
Nature Communications, 2011 Severe vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma ...
Howard, Amber Cyran +2 more
openaire +3 more sources
Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]
, 2016 Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne +3 more
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Plasma membrane repairs by small GTPase Rab3a [PDF]
Journal of Cell Biology, 2016 Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane ...
Camilla Raiborg, Harald Stenmark
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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
doaj +1 more source
The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]
, 2015 Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S +5 more
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A new twist on plasma membrane repair [PDF]
Communicative & Integrative Biology, 2011 Cells in multicellular organisms are under constant mechanical stress, and often the plasma membrane (PM) is compromised. Fortunately, there is a vigorous repair mechanism that rapidly (within seconds) reseals the wound site by fusion with an internal membrane patch.
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Connexin communication compartments and wound repair in epithelial tissue [PDF]
, 2018 Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc +4 more
core +4 more sources
Effect of Antarctic Krill Oil Supplementation on Skeletal Muscle Plasma Membrane Repair in Mice after Exhaustive Exercise [PDF]
Shipin Kexue, 2023 Objective: To investigate the effects of supplementation of Antarctic krill oil (KO) on muscle plasma membrane injury and functional recovery in mice after exhaustive exercise, and to explore the possible mechanism by which KO supplementation promotes ...
YANG Simeng, HE Qing, SHI Lijun, WU Ying
doaj +1 more source