Results 61 to 70 of about 315,200 (280)

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration [PDF]

, 2009
Nucleoporin Nup62 localizes at the central channel of the nuclear pore complex and is essential for nucleocytoplasmic transport. Through its FG-repeat domain, Nup62 regulates nuclear pore permeability and binds nuclear transport receptors.
Bayliss, Bayliss, Bernad, Blower, Boyd, Bradford, Brown, Buss, Caswell, Cho, Clarkson, Dawlaty, De Corte, Dultz, Frey, Grindstaff, Gromley, He, Hsu, Inoue, Jeganathan, Joseph, Joseph, Kalverda, Kasper, Kawase, Kawato, Kirsh, Lee, Liu, Loiodice, Macaulay, Matunis, Melcak, Moore, Munson, Nagai, Orjalo, Oztan, Palancade, Palancade, Paschal, Pommereit, Prigent, Rabut, Rittmeyer, Rosse, Sakurai-Yageta, Schrader, Schwarz-Herion, Stewart, Taddei, Tayeb, Terry, Towbin, Van Impe, Wang, Ward, Yeaman, Zimmermann, Zuccolo, Zuo   +61 more
core   +1 more source

The SNARE complex formed by RIC-4/SEC-22/SYX-2 promotes C. elegans epidermal wound healing

Cell Reports, 2023
Summary: Maintaining cellular viability relies on the integrity of the plasma membrane, which must be repaired upon damage. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is a crucial mechanism ...
Qingfang Shao, Chandra Sugiarto Wijaya, Shen Wang, Xinan Meng, Cheng Yuan, Cong Ma, Suhong Xu   +6 more
doaj   +1 more source

HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification [PDF]

, 2017
Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at the trans-Golgi network (TGN), where their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis are ...
Asensio, Cedric S, Burns, Christian, Chen, Lan, de Leeuw, Noah F, Fitzpatrick, James A. J., Hosford, Bethany, Hummer, Blake H, Joens, Matthew S   +7 more
core   +2 more sources

Defective membrane repair machinery impairs survival of invasive cancer cells

Scientific Reports, 2020
Cancer cells are able to reach distant tissues by migration and invasion processes. Enhanced ability to cope with physical stresses leading to cell membrane damages may offer to cancer cells high survival rate during metastasis.
F. Bouvet, M. Ros, E. Bonedeau, C. Croissant, L. Frelin, F. Saltel, V. Moreau, A. Bouter   +7 more
doaj   +1 more source

HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons [PDF]

, 2013
Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth factors are widely used in orthopaedic/sports medicine to repair injured tendons.
A Mishra, A Schneider, AR Amin, B Christensen, B Christensen, BA Kerr, C Gabay, C Hsu, C Molnar, Cristoforo Scavone, DL Butler, DW Gilroy, DW Gilroy, E Anitua, E Homsi, F Cilli, Freddie H. Fu, G Yang, H El-Sharkawy, Hee-Jeong Im, J Damm, J Zhang, J Zhang, J Zhang, J Zhang, James H-C. Wang, JC Peerbooms, JC Peerbooms, JH Wang, JH Wang, Jianying Zhang, K Takai, Kellie K. Middleton, KM Khan, L Engebretsen, LC Almekinders, M Giannopoulou, M Okada, M Tsuzaki, MH Khan, MM Murray, MM Murray, MM Wolfe, P Bendinelli, P Renstrom, R Gong, RE Marx, RJ de Vos, S Fiorucci, S Nakamura, S Narumiya, SH Ferreira, ST Ferry, T Kaido, T Molloy, TE Foster, TJ Williams, U Sheth, UC Kopp, WL Smith, YH Kang, Z Li   +61 more
core   +1 more source

Membrane repair against H. pylori promotes cancer cell proliferation [PDF]

, 2010
Membrane repair is a universal response against physical and biological insults and enables cell survival. Helicobacter pylori is one of the most common human pathogens and the first formally recognized bacterial carcinogen associated with gastric cancer.
Chiung-Nien Chen, Hsuan-Cheng Huang, Hsueh-Fen Juan, Jin-Town Wang, Li-Ling Lin, Satoshi Ogihara   +5 more
core   +1 more source

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis [PDF]

The Journal of Cell Biology, 2008
Ca2+ influx through plasma membrane lesions triggers a rapid repair process that was previously shown to require the exocytosis of lysosomal organelles (Reddy, A., E. Caler, and N. Andrews. 2001. Cell. 106:157–169). However, how exocytosis leads to membrane resealing has remained obscure, particularly for stable lesions caused by pore-forming proteins.
Idone, Vincent, Tam, Christina, Goss, John W., Toomre, Derek, Pypaert, Marc, Andrews, Norma W.   +5 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Muscle membrane repair and inflammatory attack in dysferlinopathy

Skeletal Muscle, 2011
Repair of plasma membrane tears is an important normal physiological process that enables the cells to survive a variety of physiological and pathological membrane lesions.
Han Renzhi
doaj   +1 more source

Mechanisms of Endothelial Cell Membrane Repair: Progress and Perspectives

Cells, 2023
Endothelial cells are the crucial inner lining of blood vessels, which are pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise ...
Duoduo Zha, Shizhen Wang, Paula Monaghan-Nichols, Yisong Qian, Venkatesh Sampath, Mingui Fu   +5 more
doaj   +1 more source