Revisiting the role of Annexins in membrane trafficking [PDF]
Cellular and Molecular Life SciencesEver since their discovery five decades ago, annexins have been implicated in membrane-related events along endo- and exocytic pathways. Over the years, structural, biochemical and cell imaging studies have revealed that annexins facilitate the ...
Jesper Nylandsted +2 more
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Comparative Cell Biology and Evolution of Annexins in Diplomonads
MSphere, 2016 Annexins are multifunctional, calcium-binding proteins found in organisms across all kingdoms. Most studies of annexins from single-celled eukaryotes have focused on the alpha-giardins, proteins assigned to the group E annexins, expressed by the ...
Asgeir Ástvaldsson +2 more
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Initial Molecular Detection of Membrane Damage in Post-Golgi Compartments [PDF]
CellsMammalian cells contain numerous membrane-bound organelles, of which endosomes serve as the initial destination for endocytosed molecules. Therapeutic agents are also internalized by cells and transported to endosomes or phagosomes and subsequently ...
Yoko Shiba, Nana Saito
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Annexins: central regulators of plant growth and stress signaling [PDF]
Acta Biochimica et Biophysica SinicaAnnexins are a family of multifunctional calcium-dependent and phospholipid-binding proteins that are widely distributed in the plant kingdom. They have a highly conserved evolutionary history that dates back to single-celled protists. Plant annexins, as
Xie Chen +5 more
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Arabidopsis fad4 mutant analysis provides insights into thermo sensing within plant plasma membrane [PDF]
Frontiers in Plant ScienceIncreasing evidence suggests that the plasma membrane is the initial site for temperature sensing. In searching for the contributions of membrane lipids to stress-induced cytosolic calcium, we found that FATTY ACID DESATURASE 4 (FAD4) knockout mutant ...
Mingjie Chen +6 more
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Annexin A6 Is a Novel Cytosolic Regulator of Multiple Inter-organelle Contact Sites [PDF]
ContactAnnexins are a widely expressed family of multifunctional cytosolic proteins with diverse cellular roles. Recent advances have uncovered new avenues for the involvement of several annexins in membrane dynamics, suggesting a potential link to the ...
Carlos Enrich +2 more
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Annexins in Influenza Virus Replication and Pathogenesis
Frontiers in Pharmacology, 2018 Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome.
Lina Lim, Sonja Chua, Wan Ting Kong
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Excess muscle plasma membrane leak disrupts ECM content and shifts macrophage-mediated muscle repair [PDF]
JCI InsightPlasma membrane repair is critical for tissue integrity, especially for elongated contractile muscle cells. Genetically mediated defects in plasma membrane resealing produce persistent leak, leading to a disordered extracellular matrix (ECM). Loss of the
GaHyun Lee +18 more
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From brain to eye: Annexin A1 and A2 as a key mediator of retinal neuroinflammation in Parkinson’s and Alzheimer’s disease [PDF]
International Journal of Retina and VitreousThe retina, as an extension of the central nervous system, is highly susceptible to inflammatory and degenerative changes similar to those brain seen in Parkinson’s disease (PD) and Alzheimer’s disease (AD).
Luiz Philipe de Souza Ferreira +1 more
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Therapeutic Potential of Annexins in Sepsis and COVID-19
Frontiers in Pharmacology, 2021 Sepsis is a continuing problem in modern healthcare, with a relatively high prevalence, and a significant mortality rate worldwide. Currently, no specific anti-sepsis treatment exists despite decades of research on developing potential therapies ...
Louise Mui +5 more
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