Revisiting the role of Annexins in membrane trafficking [PDF]
Cellular and Molecular Life SciencesEver since their discovery five decades ago, annexins have been implicated in membrane-related events along endo- and exocytic pathways. Over the years, structural, biochemical and cell imaging studies have revealed that annexins facilitate the ...
Jesper Nylandsted +2 more
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Annexins: central regulators of plant growth and stress signaling [PDF]
Acta Biochimica et Biophysica SinicaAnnexins are a family of multifunctional calcium-dependent and phospholipid-binding proteins that are widely distributed in the plant kingdom. They have a highly conserved evolutionary history that dates back to single-celled protists. Plant annexins, as
Xie Chen +5 more
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Arabidopsis fad4 mutant analysis provides insights into thermo sensing within plant plasma membrane [PDF]
Frontiers in Plant ScienceIncreasing evidence suggests that the plasma membrane is the initial site for temperature sensing. In searching for the contributions of membrane lipids to stress-induced cytosolic calcium, we found that FATTY ACID DESATURASE 4 (FAD4) knockout mutant ...
Mingjie Chen +6 more
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Comparative Cell Biology and Evolution of Annexins in Diplomonads
MSphere, 2016 Annexins are multifunctional, calcium-binding proteins found in organisms across all kingdoms. Most studies of annexins from single-celled eukaryotes have focused on the alpha-giardins, proteins assigned to the group E annexins, expressed by the ...
Asgeir Ástvaldsson +2 more
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Plant StressPlant annexins are a multigene family of phospholipid-binding, calcium-dependent proteins that respond to signals and environmental challenges as plants grow and develop.
Pravej Alam +2 more
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Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics [PDF]
Nature CommunicationsAnnexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels.
Volker Gerke +6 more
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Annexins and autoantibodies in autoimmune diseases – Insights into SLE, APS and RA: A review [PDF]
Biomolecules & BiomedicineAutoimmune diseases are becoming increasingly prevalent and can cause multi-organ damage through dysregulated immune responses to self-antigens. This review aims to summarize the roles of annexin family proteins and annexin autoantibodies in the ...
Xiuli Zhou +5 more
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From brain to eye: Annexin A1 and A2 as a key mediator of retinal neuroinflammation in Parkinson’s and Alzheimer’s disease [PDF]
International Journal of Retina and VitreousThe retina, as an extension of the central nervous system, is highly susceptible to inflammatory and degenerative changes similar to those brain seen in Parkinson’s disease (PD) and Alzheimer’s disease (AD).
Luiz Philipe de Souza Ferreira +1 more
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Therapeutic Potential of Annexins in Sepsis and COVID-19
Frontiers in Pharmacology, 2021 Sepsis is a continuing problem in modern healthcare, with a relatively high prevalence, and a significant mortality rate worldwide. Currently, no specific anti-sepsis treatment exists despite decades of research on developing potential therapies ...
Louise Mui +5 more
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Bioinformatics analysis of bacterial annexins--putative ancestral relatives of eukaryotic annexins. [PDF]
PLoS ONE, 2014 Annexins are Ca(2+)-binding, membrane-interacting proteins, widespread among eukaryotes, consisting usually of four structurally similar repeated domains. It is accepted that vertebrate annexins derive from a double genome duplication event.
Praveen Kumar Kodavali +3 more
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