Results 21 to 30 of about 5,734 (257)
Interplay of membrane crosslinking and curvature induction by annexins
Scientific Reports, 2022 Efficient plasma membrane repair (PMR) is required to repair damage sustained in the cellular life cycle. The annexin family of proteins, involved in PMR, are activated by Ca2+ influx from extracellular media at the site of injury. Mechanistic studies of
Anna Mularski +6 more
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Annexins and cardiovascular diseases: Beyond membrane trafficking and repair
Frontiers in Cell and Developmental Biology, 2022 Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. The main cause underlying CVD is associated with the pathological remodeling of the vascular wall, involving several cell types, including endothelial cells, vascular smooth ...
Nerea Méndez-Barbero +10 more
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Molecules, 2022 Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente +4 more
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Glycosylation of annexin I and annexin II
Biochemical and Biophysical Research Communications, 1992 Human placental annexin I and annexin II were shown to be glycosylated by one-dimensional affinity blotting with the lectin concanavalin A, which recognizes D-mannose and D-glucose residues. Further evidence that annexin I and annexin II are glycosylated was provided by the finding that these proteins incorporated D-[2,6-3H]mannose and D-[6-3H]glucose ...
F, Goulet, K G, Moore, A C, Sartorelli
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European Journal of Cell Biology, 2006 Annexins are a highly conserved ubiquitous family of Ca2+- and phospholipid-binding proteins present in nearly all eukaryotic cells. Analysis of the Dictyostelium genome revealed the presence of two annexin genes, the annexin C1 gene (nxnA) giving rise to two isoforms of 47 and 51 kDa (previously synexin), and the annexin C2 gene (nxnB) coding for a 56-
Marija, Marko +5 more
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Therapeutic Potential of Annexin A1 Modulation in Kidney and Cardiovascular Disorders
Cells, 2021 Renal and cardiovascular disorders are very prevalent and associated with significant morbidity and mortality. Among diverse pathogenic mechanisms, the dysregulation of immune and inflammatory responses plays an essential role in such disorders ...
Mahmood S. Mozaffari
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Annexins Bridging the Gap: Novel Roles in Membrane Contact Site Formation
Frontiers in Cell and Developmental Biology, 2022 Membrane contact sites (MCS) are specialized small areas of close apposition between two different organelles that have led researchers to reconsider the dogma of intercellular communication via vesicular trafficking.
Carlos Enrich +8 more
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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
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International Journal of Molecular Sciences, 2018 Glaucoma is one of the leading causes of irreversible visual loss, which has been estimated to affect 3.5% of those over 40 years old and projected to affect a total of 112 million people by 2040. Such a dramatic increase in affected patients demonstrates the need for continual improvement in the way we diagnose and treat this condition.
Timothy E. Yap +4 more
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Annexins in Influenza Virus Replication and Pathogenesis
Frontiers in Pharmacology, 2018 Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome.
Patrick Baah Ampomah +6 more
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