Results 31 to 40 of about 7,097 (288)
Molecules, 2022 Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente +4 more
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European Journal of Cell Biology, 2006 Annexins are a highly conserved ubiquitous family of Ca2+- and phospholipid-binding proteins present in nearly all eukaryotic cells. Analysis of the Dictyostelium genome revealed the presence of two annexin genes, the annexin C1 gene (nxnA) giving rise to two isoforms of 47 and 51 kDa (previously synexin), and the annexin C2 gene (nxnB) coding for a 56-
Marija, Marko +5 more
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Therapeutic Potential of Annexin A1 Modulation in Kidney and Cardiovascular Disorders
Cells, 2021 Renal and cardiovascular disorders are very prevalent and associated with significant morbidity and mortality. Among diverse pathogenic mechanisms, the dysregulation of immune and inflammatory responses plays an essential role in such disorders ...
Mahmood S. Mozaffari
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The annexins: spatial and temporal coordination of signaling events during cellular stress [PDF]
, 2009 Annexins are a family of structurally related, Ca2+-sensitive proteins that bind to negatively charged phospholipids and establish specific interactions with other lipids and lipid microdomains. They are present in all eukaryotic cells and share a common
Draeger, Annette +2 more
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Annexins Bridging the Gap: Novel Roles in Membrane Contact Site Formation
Frontiers in Cell and Developmental Biology, 2022 Membrane contact sites (MCS) are specialized small areas of close apposition between two different organelles that have led researchers to reconsider the dogma of intercellular communication via vesicular trafficking.
Carlos Enrich +8 more
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International Journal of Molecular Sciences, 2018 Glaucoma is one of the leading causes of irreversible visual loss, which has been estimated to affect 3.5% of those over 40 years old and projected to affect a total of 112 million people by 2040. Such a dramatic increase in affected patients demonstrates the need for continual improvement in the way we diagnose and treat this condition.
Timothy E. Yap +4 more
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Extracellular annexins in hemostasis system [PDF]
, 2016 Annexins are calcium-binding proteins that interact with cellular membranes due to their ability to bind phospholipids. The structural and functional peculiarities of these proteins have been described.
Zhernossekov, D.D. +2 more
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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
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Annexins and protein kinases C [PDF]
, 1996 Annexins and protein kinases C belong to two distinct families of ubiquitous cytoplasmic proteins involved in signal transduction. All annexins share the property of binding calcium and phospholipids in the presence of calcium.
Mira, Jean Paul +3 more
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Vesicular traffic in polarized epithelial cells : identification and characterization of general and epithelial specific factors [PDF]
, 1994 Polarized epithelial cells are differentiated into apical and basolateral plasma membrane domains separated by tight junctions. The apical cell surface usually faces the external milieu, the basolateral domain provides cell-cell and cell-substratum ...
Fiedler, Klaus
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