Results 11 to 20 of about 1,073 (201)

Annexins as disease modifiers. [PDF]

Histology and histopathology, 2010
The annexins are a family of calcium-dependent phospholipid binding proteins which are present in all eukaryotes. There are currently 12 identified human annexins all of which contain unique calcium binding sites, encoded in the highly conserved annexin repeat motifs within the C terminal core.
Fatimathas, Lux, Moss, Stephen E.
openaire   +4 more sources

Functional Association between Regulatory RNAs and the Annexins [PDF]

, 2018
Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of
Katia Monastyrskaya, Monastyrskaya-Stäuber, Katia   +1 more
core   +1 more source

The annexins: spatial and temporal coordination of signaling events during cellular stress [PDF]

, 2009
Annexins are a family of structurally related, Ca2+-sensitive proteins that bind to negatively charged phospholipids and establish specific interactions with other lipids and lipid microdomains. They are present in all eukaryotic cells and share a common
Draeger, Annette, Monastyrskaya, Katia, Babiychuk, Eduard B   +2 more
core   +1 more source

Extracellular annexins in hemostasis system [PDF]

, 2016
Annexins are calcium-binding proteins that interact with cellular membranes due to their ability to bind phospholipids. The structural and functional peculiarities of these proteins have been described.
Zhernossekov, D.D., Roka-Moiia, Y.M., Grinenko, T.V.   +2 more
core   +1 more source

Vesicular traffic in polarized epithelial cells : identification and characterization of general and epithelial specific factors [PDF]

, 1994
Polarized epithelial cells are differentiated into apical and basolateral plasma membrane domains separated by tight junctions. The apical cell surface usually faces the external milieu, the basolateral domain provides cell-cell and cell-substratum ...
Fiedler, Klaus
core   +1 more source

Role of Annexins in Vascular Hemostasis

, 2021
Since our understanding of the existence of the Annexin family a vast amount of data dealing with structural and functional aspects of Annexins has appeared in the literature.
Reutelingsperger, Chris P.M.
core   +1 more source

Interplay of membrane crosslinking and curvature induction by annexins [PDF]

, 2022
Efficient plasma membrane repair (PMR) is required to repair damage sustained in the cellular life cycle. The annexin family of proteins, involved in PMR, are activated by Ca2+ influx from extracellular media at the site of injury. Mechanistic studies of
Nylandsted, Jesper, Khandelia, Himanshu, Himanshu Khandelia, Pandey, Mayank Prakash, Simonsen, Adam Cohen, Mayank Prakash Pandey, Khandelia, Himanshu; id_orcid, Anne Sofie Busk Heitmann, Adam Cohen Simonsen, Jesper Nylandsted, Heitmann, Anne Sofie Busk, Simonsen, Adam Cohen; id_orcid, Stine Lauritzen Sønder, Mularski, Anna, Anna Mularski, Sønder, Stine Lauritzen   +15 more
core   +1 more source

Annexins sense changes in intracellular pH during hypoxia

, 2007
The pH(i) (intracellular pH) is an important physiological parameter which is altered during hypoxia and ischaemia, pathological conditions accompanied by a dramatic decrease in pH(i).
Eduard B. Babiychuk, Katia Monastyrskaya, Stroka, Deborah, Draeger, Annette, Tschumi, Fabian, Monastyrskaya, Katia, Babiychuk, Eduard B, Annette Draeger, Fabian Tschumi, Deborah Stroka   +9 more
core   +1 more source

Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization

, 2009
Initiation of mineralization during endochondral ossification is a multistep process and has been assumed to correlate with specific interactions of annexins A5 and A6 and collagens.
Pausch, F, Rosenbaum, S, Poschl, E, Grskovic, I, Etich, J, Frie, C, Schlotzer-Schrehardt, U, Bateman, JF, Niehoff, A, Belluoccio, D, Moss, SE, Brachvogel, B   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source