Results 31 to 40 of about 315,200 (280)
Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential
Cells, 2022 The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li +6 more
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iScience, 2021 Summary: The plasma membrane repair holds significance for maintaining cell survival and homeostasis. To achieve the sensitive visualization of membrane repair process for revealing its mechanism, this work designs a perforation-induced surface-enhanced ...
Yuanjiao Yang +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 After damage, cells repair their plasma membrane in an active process that is driven by Ca2+ entering through the wound. This triggers a range of Ca2+-regulated events such as the translocation of different Ca2+-binding proteins to the wound site which ...
Arsila P. K. Ashraf, Volker Gerke
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Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform [PDF]
, 2013 Intracellular delivery of materials is a challenge in research and therapeutic applications. Physical methods of plasma membrane disruption have recently emerged as an approach to facilitate the delivery of a variety of macromolecules to a range of cell ...
Cho, Nahyun +11 more
core +1 more source
Requirement for Annexin A1 in Plasma Membrane Repair [PDF]
Journal of Biological Chemistry, 2006 Ca2+ entering a cell through a torn or disrupted plasma membrane rapidly triggers a combination of homotypic and exocytotic membrane fusion events. These events serve to erect a reparative membrane patch and then anneal it to the defect site. Annexin A1 is a cytosolic protein that, when activated by micromolar Ca2+, binds to membrane phospholipids ...
Anna K, McNeil +3 more
openaire +2 more sources
Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes
Frontiers in Medicine, 2022 Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care patients, but the mechanisms causing this severe syndrome are still poorly understood.
Andrey V. Kozlov +5 more
doaj +1 more source
PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers. [PDF]
, 2019 Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) are orthobiologic therapies considered as an alternative to the current therapies for muscle, bone and cartilage. Different formulations of biomaterials have been used as carriers for
Shams, Shahin +3 more
core +1 more source
Plasma membrane wounding and repair in pulmonary diseases [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2017 Various pathophysiological conditions such as surfactant dysfunction, mechanical ventilation, inflammation, pathogen products, environmental exposures, and gastric acid aspiration stress lung cells, and the compromise of plasma membranes occurs as a result.
Xiaofei, Cong +3 more
openaire +2 more sources
Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage
Advanced Science, 2023 The plasma membrane of a cell is subject to stresses causing ruptures that must be repaired immediately to preserve membrane integrity and ensure cell survival.
Nikita Raj +9 more
doaj +1 more source
Calpains, Cleaved Mini-Dysferlin(C72), and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair [PDF]
, 2013 Dysferlin is proposed as a key mediator of calcium-dependent muscle membrane repair, although its precise role has remained elusive. Dysferlin interacts with a new membrane repair protein, mitsugumin 53 (MG53), an E3 ubiquitin ligase that shows rapid ...
Cooper, ST +8 more
core +3 more sources