Results 31 to 40 of about 173,214 (234)
Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes
Frontiers in Medicine, 2022 Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care patients, but the mechanisms causing this severe syndrome are still poorly understood.
Andrey V. Kozlov +5 more
doaj +1 more source
Requirement for Annexin A1 in Plasma Membrane Repair [PDF]
Journal of Biological Chemistry, 2006 Ca2+ entering a cell through a torn or disrupted plasma membrane rapidly triggers a combination of homotypic and exocytotic membrane fusion events. These events serve to erect a reparative membrane patch and then anneal it to the defect site. Annexin A1 is a cytosolic protein that, when activated by micromolar Ca2+, binds to membrane phospholipids ...
Anna K, McNeil +3 more
openaire +2 more sources
Plasma membrane wounding and repair in pulmonary diseases [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2017 Various pathophysiological conditions such as surfactant dysfunction, mechanical ventilation, inflammation, pathogen products, environmental exposures, and gastric acid aspiration stress lung cells, and the compromise of plasma membranes occurs as a result.
Xiaofei, Cong +3 more
openaire +2 more sources
Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage
Advanced Science, 2023 The plasma membrane of a cell is subject to stresses causing ruptures that must be repaired immediately to preserve membrane integrity and ensure cell survival.
Nikita Raj +9 more
doaj +1 more source
Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair.
PLoS Curr, 2015 Dysferlin is a sarcolemmal protein that is defective in Miyoshi myopathy and limb-girdle muscular dystrophy type 2B, and is involved in sarcolemmal repair. Primary cultured myoblasts and myotubes established from patient muscle biopsies have been widely utilized to explore the molecular mechanism of dysferlinopathy.The purpose of this study was to ...
Matsuda C +4 more
europepmc +3 more sources
Promotion of plasma membrane repair by vitamin E [PDF]
Nature Communications, 2011 Severe vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma ...
Howard, Amber Cyran +2 more
openaire +3 more sources
Plasma membrane repairs by small GTPase Rab3a [PDF]
Journal of Cell Biology, 2016 Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane ...
Camilla Raiborg, Harald Stenmark
openaire +2 more sources
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
doaj +1 more source
A new twist on plasma membrane repair [PDF]
Communicative & Integrative Biology, 2011 Cells in multicellular organisms are under constant mechanical stress, and often the plasma membrane (PM) is compromised. Fortunately, there is a vigorous repair mechanism that rapidly (within seconds) reseals the wound site by fusion with an internal membrane patch.
openaire +2 more sources
Two-way traffic on the road to plasma membrane repair [PDF]
Trends in Cell Biology, 2008 Ca(2+) influx through plasma membrane wounds triggers a rapid-repair response that is essential for cell survival. Earlier studies showed that repair requires the exocytosis of intracellular vesicles. Exocytosis was thought to promote resealing by 'patching' the plasma membrane lesion or by facilitating bilayer restoration through reduction in membrane
Vincent, Idone +2 more
openaire +2 more sources