Results 61 to 70 of about 3,363,706 (303)

Unremodeled GPI-anchored proteins at the plasma membrane trigger aberrant endocytosis

Life Science Alliance
A unique plasma membrane stressor induces vacuolar degradation of abnormally endocytosed proteins. The plasma membrane has a complex organization that includes the polarized distribution of membrane proteins and lipids.
Li Chen, David K Banfield
doaj   +1 more source

The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

BMC Cell Biology, 2018
Background Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with constitutive RhoGEF activity.
J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella, M. Postma, J. Goedhart   +7 more
doaj   +1 more source

Lipid Organization of the Plasma Membrane

Journal of the American Chemical Society, 2014
The detailed organization of cellular membranes remains rather elusive. Based on large-scale molecular dynamics simulations, we provide a high-resolution view of the lipid organization of a plasma membrane at an unprecedented level of complexity. Our plasma membrane model consists of 63 different lipid species, combining 14 types of headgroups and 11 ...
Ingólfsson, Helgi I, Melo, Manuel N, van Eerden, Floris J, Arnarez, Clément, Lopez, Cesar A, Wassenaar, Tsjerk A, Periole, Xavier, de Vries, Alex H, Tieleman, D Peter, Marrink, Siewert J   +9 more
openaire   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The effect of modulating membrane lipid composition on the thermal sensitivity of tumour cells in culture [PDF]

, 1989
The plasma membrane, which separates intracellular contents from extra cellular milieu, consists of a lipid bilayer comprising mainly phospholipids and cholesterol together with various functional proteins, which control the interaction of the cell with ...
Kingston, Catharine Alison
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton [PDF]

, 1999
CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells.
Ursula Günthert, Günthert, U., Huber, L. A., Beug, H., Hartmut Beug, Gerke, V., Thomas Harder, Paiha, K., Volker Gerke, Oliferenko, S., Schwarz, H., Karin Paiha, Heinz Schwarz, Harder, T., Snezhana Oliferenko, Lukas A. Huber, Christoph Schwärzler, Schwärzler, C.   +17 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Protein diffusion in plant cell plasma membranes: The cell-wall corral

Frontiers in Plant Science, 2013
Studying protein diffusion informs us about how proteins interact with their environment. Work on protein diffusion over the last several decades has illustrated the complex nature of biological lipid bilayers.
Alexandre eMartinière, John eRunions
doaj   +1 more source

Fluorescence Resonance Energy Transfer to Detect Plasma Membrane Perturbations in Giant Plasma Membrane Vesicles

Bio-Protocol, 2023
Disruptions and perturbations of the cellular plasma membrane by peptides have garnered significant interest in the elucidation of biological phenomena.
Mathew Sebastiao, Noe Quittot, Isabelle Marcotte, Steve Bourgault   +3 more
doaj   +1 more source