Results 41 to 50 of about 3,494,280 (302)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Conceptual design of CFETR ECRH equatorial launcher and upper launcher [PDF]

EPJ Web of Conferences, 2019
The Electron Cyclotron Resonance Heating (ECRH) system of China Fusion Engineering Test Reactor (CFETR) is designed to inject 20 MW RF power into the plasma for heating and current drive (H&CD) applications.
Tang Yunying, Liu Fukun, Wang Xiaojie, Wei Wei, Zhang Liyuan, Xu Handong, Wu Dajun, Xu Weiye, Wang Jian   +8 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Plans for the first plasma operation of Wendelstein 7-X [PDF]

, 2015
Wendelstein 7-X (W7-X) is currently under commissioning in preparation for its initial plasma operation phase, operation phase 1.1 (OP1.1). This first phase serves primarily to provide an integral commissioning of all major systems needed for plasma ...
Hoelbe, H., Bosch, H. -S., Hartmann, D., Andreeva, T., Preynas, M., Endler, M., Otte, M., Pedersen, T., Bosch, H., Turkin, Y., Feng, Y., Andreeva, T. ; https://orcid.org/, Jakubowski, M., Stange, T., Gates, D., Bozhenkov, S., Effenberg, F., Schmitz, O., Lazerson, S., Geiger, J., Pedersen, T. Sunn, König, R., Laqua, H., Koenig, R., Hölbe, H., Gates, D. A., Laqua, H. P.   +26 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Plasma turbulence, suprathermal ion dynamics and code validation on the basic plasma physics device TORPEX

The TORPEX basic plasma physics device at the Center for Plasma Physics Research (CRPP) in Lausanne, Switzerland is described. In TORPEX, simple magnetized toroidal configurations, a paradigm for the tokamak scrape-off layer (SOL), as well as more ...
Bovet, A., Poli, F. M., Avino, F., Loizu, J., Fasoli, A., Furno, I., Labit, B., Theiler, C., Mueller, S. H., Diallo, A., Iraji, D., Plyushchev, G., Podesta, M., Gustafson, K., Ricci, P.   +14 more
core   +1 more source

Energy coupling among the degrees of freedom in an electron-positron plasma [PDF]

, 2010
Nonlinear coupling of the motion in the three spatial degrees of freedom of a cold fluid electron-positron plasma is investigated. Exact, solutions describing expanding flows with oscillations are obtained. It is found that the energy in the irrotational
Karimov, A R,, Stenflo, Lennart,, Y Yu, M,, A. R. KARIMOV, Y Yu, M, M. Y. YU, WENMIN ZHANG, Stenflo, Lennart, Zhang, Wenmin, Karimov, A R, Zhang, Wenmin,, L. STENFLO   +11 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Performance optimisation of tokamak operation in ASDEX Upgrade through novel feedback control capabilities

Nuclear Fusion
Optimising the performance of tokamak operation is not only a matter of tuning individual control loops, but needs a holistic approach with a focus on the effective interplay of all control system components.
W. Treutterer, M. Biasizzo, P. David, E. Fable, M. Gehring, L. Giannone, I. Gomez, A. Gräter, J. Illerhaus, R. Kermenov, D. Kropackova, O. Kudlacek, G. Raupp, M. Reisner, B. Sieglin, M. Weiland, T. Zehetbauer, the ASDEX Upgrade Team   +17 more
doaj   +1 more source