Results 41 to 50 of about 3,109,302 (300)

Designing a tokamak fusion reactor—How does plasma physics fit in?

, 2015
This paper attempts to bridge the gap between tokamak reactor design and plasma physics. The analysis demonstrates that the overall design of a tokamak fusion reactor is determined almost entirely by the constraints imposed by nuclear physics and fusion ...
Mangiarotti, Franco Julio, Minervini, Joseph V, Freidberg, Jeffrey P.   +2 more
core   +1 more source

Self-consistent nonlinear kinetic simulations of the anomalous Doppler instability of suprathermal electrons in plasmas [PDF]

, 2013
Suprathermal tails in the distributions of electron velocities parallel to the magnetic field are found in many areas of plasma physics, from magnetic confinement fusion to solar system plasmas.
R. O. Dendy, Lai, W. N., Dendy, R. O., S. C. Chapman, W. N. Lai, Chapman, Sandra C.   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transport properties of disordered 2D complex plasma crystal

, 2018
In this work, we investigate numerically the transport properties of a 2D complex plasma crystal using diffusion of coplanar dust lattice waves. In the limit where the Hamiltonian interactions can be decoupled from the non-Hamiltonian effects, we ...
Busse, Kyle, Guyton, Forrest., Cameron, Adam., Matthews, Lorin Swint., Liaw, Constanze., Cameron, Adam, Busse, Kyle., Kostadinova, Eva Georgieva, 1992-, Hyde, Truell Wayne.   +8 more
core   +1 more source

Conceptual design of CFETR ECRH equatorial launcher and upper launcher [PDF]

EPJ Web of Conferences, 2019
The Electron Cyclotron Resonance Heating (ECRH) system of China Fusion Engineering Test Reactor (CFETR) is designed to inject 20 MW RF power into the plasma for heating and current drive (H&CD) applications.
Tang Yunying, Liu Fukun, Wang Xiaojie, Wei Wei, Zhang Liyuan, Xu Handong, Wu Dajun, Xu Weiye, Wang Jian   +8 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Princeton Plasma Physics Laboratory [PDF]

, 1990
This report discusses the following topics: principal parameters achieved in experimental devices fiscal year 1990; tokamak fusion test reactor; compact ignition tokamak; Princeton beta experiment- modification; current drive experiment-upgrade ...

core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source