Results 41 to 50 of about 70,052 (258)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Charge resolved electrostatic diagnostic of colliding copper laser plasma plumes [PDF]

, 2011
The collision of two laser generated plasma plumes can result, under appropriate conditions, in the formation of ‘stagnation layer’. The processes underlying this phenomenon are complex and time dependent.
Yeates, P., Costello, John T., P. Yeates, J. T. Costello, E. T. Kennedy, Kennedy, E.T., C. Fallon, Fallon, Conor   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Effect of Density Irregularities on Radio Frequency Wave Propagation in Ionospheric Plasmas [PDF]

EPJ Web of Conferences
Density irregularities play a vital role in determining how radio frequency (RF) waves travel through plasmas. In the Earth’s ionosphere, these density irregularities also impact radio communication.
Kim Eun-Hwa, Johnson Jay R., Shiraiwa Syun’ichi, Bertelli Nicola, Ono Masayuki, Wing Simon   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Improved liquid lithium surfaces in the Lithium Tokamak Experiment-β

Nuclear Materials and Energy
Advances in vacuum, surface, and lithium conditioning techniques throughout five years of continuous operations in LTX-β have produced mirror-like liquid lithium surfaces and demonstrated the feasibility of high-performance tokamak discharges fully ...
D.P. Boyle, A. Maan, R. Majeski, E. Ostrowski, S. Abe, S. Banerjee, W. Capecchi, D.B. Elliott, C. Hansen, E. Jung, P.E. Hughes, S. Kubota, M. Lampert, R. Maingi, A.G. McLean, J.E. Menard, J.J. Morales, V.A. Soukhanovskii   +17 more
doaj   +1 more source

Dynamic edge transport investigations at ASDEX Upgrade using gas puff modulation

Nuclear Fusion, 2023
Gas puff modulation experiments are performed at ASDEX Upgrade in L-mode, EDA H-mode and quasi-continuous exhaust discharges. Plasma density and temperatures are measured and their temporal development is analyzed simultaneously, revealing that both heat
C.U. Schuster, E. Wolfrum, T. Görler, E. Fable, R. Fischer, M. Griener, B. Tal, C. Angioni, P. Manz, U. Stroth, the ASDEX Upgrade Team   +10 more
doaj   +1 more source

Spectral and temporal behavior of an alkali metal plasma extreme ultraviolet source for surface morphology applications

, 2011
We have characterized the emission spectrum and temporal history of a pure potassium plasma in a capillary discharge. Strong broadband emission was observed around 40 nm due to 3s−3p, 3p−3d, and 3d−4f transitions in ions ranging from K2+ to K4+ at a time-
Noboru Yugami, Takamitsu Otsuka, Yugami, Noboru, Terauchi, Hiromitsu, Yamaguchi, Mami, O'Sullivan, Gerry, D\u27Arcy, Rebekah, Higashiguchi, Takeshi, Yatagai, Toyohiko, Mami Yamaguchi, Dunne, Padraig, O\u27Sullivan, Gerry, D'Arcy, Rebekah, Toyohiko Yatagai, Hiromitsu Terauchi, Rebekah D’Arcy, Padraig Dunne, Takeshi Higashiguchi, Gerry O’Sullivan, Otsuka, Takamitsu   +19 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source