Results 151 to 160 of about 550,587 (345)

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Adiposity, aldosterone and plasma renin activity among African Americans: The Jackson Heart Study. [PDF]

Endocr Metab Sci, 2023
Lee G, Kluwe B, Zhao S, Kline D, Nedungadi D, Brock GN, Odei JB, Kesireddy V, Pohlman N, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Echouffo-Tcheugui J, Golden SH, Joseph JJ.   +16 more
europepmc   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Bi-allelic REN Mutations and Undetectable Plasma Renin Activity in a Patient With Progressive CKD. [PDF]

Kidney Int Rep, 2023
Jorge S, Kidd K, Vylet'al P, Nogueira E, Martin L, Howard K, Barešová V, Hodaňová K, Hnízda A, Moldovan O, Silveira C, Coutinho AM, Lopes JA, Bleyer AJ, Kmoch S, Živná M.   +15 more
europepmc   +1 more source

Tools to Predict Unilateral Primary Aldosteronism and Optimise Patient Selection for Adrenal Vein Sampling: A Systematic Review

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Primary aldosteronism (PA), the most common endocrine cause of hypertension, is evaluated using adrenal vein sampling (AVS), to determine if aldosterone excess is bilateral or unilateral. AVS is invasive and technically challenging; it would ideally be used only in those with unilateral PA who are candidates for surgical cure.
Elisabeth Ng, Stella May Gwini, Winston Zheng, Peter J. Fuller, Jun Yang   +4 more
wiley   +1 more source

The spectrum of plasma renin activity and hypertension diseases: Utility, outlook, and suggestions. [PDF]

J Clin Lab Anal, 2022
Liu Z, Jin L, Zhou W, Zhang C.
europepmc   +1 more source

The Role of Renal Nerves and Prostaglandins in Control of Renal Hemodynamics and Plasma Renin Activity during Hypotensive Hemorrhage in the Dog [PDF]

, 1978
William L. Henrich, Robert J. Anderson, Arnold S. Berns, Keith M. McDonald, Penny J. Paulsen, Tomás Berl, Robert W. Schrier   +6 more
openalex   +1 more source

Prevalence of Metabolic‐Associated Steatotic Liver Disease in Patients With Primary Aldosteronism

Clinical Endocrinology, Volume 102, Issue 6, Page 618-625, June 2025.
ABSTRACT Objective To assess the prevalence of metabolic associated steatotic liver disease (MASLD) in patients with primary aldosteronism (PA) compared to benign adrenal adenomas, and to evaluate the impact of hormonal excess in inducing MASLD. Design Single‐centre retrospective study. Methods Hepatic steatosis was assessed by liver/spleen (L/S) ratio
Irene Tizianel, Alberto Madinelli, Filippo Crimì, Mattia Barbot, Simona Censi, Chiara Sabbadin, Filippo Ceccato   +6 more
wiley   +1 more source

Effect of a SGLT2 inhibitor on the systemic and intrarenal renin–angiotensin system in subtotally nephrectomized rats

Journal of Pharmacological Sciences, 2018
We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin–angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD).
Lei Li, Yoshio Konishi, Takashi Morikawa, Yifan Zhang, Chizuko Kitabayashi, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama   +10 more
doaj  

Characteristics of aldosterone-producing adenomas in patients without plasma renin activity suppression. [PDF]

PLoS One, 2022
Kubo H, Tsurutani Y, Inoue K, Watanabe K, Yamazaki Y, Sunouchi T, Hoshino Y, Hirose R, Katsuragawa S, Tannai H, Shibahara Y, Kakuta Y, Matsui S, Saito J, Omura M, Sasano H, Nishikawa T.   +16 more
europepmc   +1 more source