Results 161 to 170 of about 44,525 (215)
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Plasma renin activity in hypertension
The American Journal of Medicine, 1967Abstract Plasma renin activity was measured in 115 patients with hypertension. Increased plasma renin activity is consistently observed in patients with malignant hypertension and in patients in whom the serum sodium is depressed. Except in such patients, increased plasma renin activity is uncommon in hypertension and has little diagnostic or ...
Morton C. Creditor, Una K. Loschky
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Radioimmunoassay of plasma renin activity
Seminars in Nuclear Medicine, 1975Plasma renin activity is quantitated by measuring the rate of angiotensin generation during incubation of plasma renin with endogenous renin substrate. The angiotensin is quantitated by radioimmunoassay. Our studies indicate that the incubation step is best carried out in undiluted plasma at the pH optimum for renin (pH 5.7) in the presence of EDTA ...
John H. Laragh, Jean E. Sealey
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Renin‐activation by kallikrein: evidence for alkaline‐activation of plasma renin
European Journal of Clinical Investigation, 1979Abstract. Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8·2. ‘Endogenous’ activation of plasma renin can be seen by incubation of plasmas at the same pH. Both ‘endogenous’ alkaline‐ and kallikrein‐activation of plasma renin can be inhibited by aprotinin.
P Ahlmann +4 more
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Activation of Rat Plasma Renin*
Endocrinology, 1981Three distinct molecular weight species of active renin, with apparent molecular weights of more than 150,000, 65,000, and 43,000 are present in the plasma of conscious rats. After acute in vivo renin stimulation (ether anesthesia and hemorrhage), however, only the low molecular weight form could be detected.
Mohinder P. Sambhi +2 more
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Plasma Renin Activity in Abortion
Acta Obstetricia et Gynecologica Scandinavica, 1976Abstract. Healthy women (N = 96) were investigated for changes in plasma renin activity (PRA) in abortion. In spontaneous abortion PRA levels were significantly lower than in induced abortion although higher than in healthy women. These findings may be explained by differences in corpus luteum function and renin production of the fetoplacental unit ...
Olof Widholm +2 more
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Hydralazine and Plasma Renin Activity
Archives of Internal Medicine, 1968On a normal diet, hydralazine hydrochloride (20 mg) given intravenously caused significant increase in plasma renin activity in five of seven normotensive subjects and ten of 20 patients with essential hypertension. Seven patients with renovascular hypertension responded to hydralazine with much greater increase; the overlap in predrug renin activity ...
Hideo Ueda +2 more
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Tryptic Activation of Plasma Renin Activity*
The Journal of Clinical Endocrinology & Metabolism, 1980Trypsinization of human plasma, like acid activation or cryoactivation, increases renin activity, as determined by subsequent enzymatic assay. In three plasma pools, tryptic activation was maximal within 2 min at a trypsin concentration of 500 micrograms/ml, decreasing at higher concentrations. Neither prolongation of trypsin exposure for up to 1 h nor
Alan T. Cariski +2 more
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Normal Plasma Renin Activity in Low Renin Hypertension
The Journal of Clinical Endocrinology & Metabolism, 1975Plasma renin activity (PRA) was measured every 4 h during a 24-h period of continuous recumbency in 10 patients with essential hypertension. All had maximum values at 12 midnight, 4 AM or 8 AM. Analysis of our date and that of others indicates that in some patients with "low renin" hypertension (LRH) these noctural peaks are of normal magnitude ...
Robert S. Modlinger, Michael Gutkin
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Plasma Cryoactivated Renin and Active Renin in Diabetes Mellitus*
The Journal of Clinical Endocrinology & Metabolism, 1981PRA and the inactive renin which is activated by cold (IR-C) were studied in a group of normal subjects and in patients with diabetes mellitus with and without the presence of nephropathy. The amount of renin activity, as measured after incubation of plasma at -5 C for 4 days, was called cold renin activity (CR.
David R. Rovner +3 more
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Suppression of Plasma Renin Activity by Cyclosporine
Journal of Urology, 1987Cyclosporine treatment is associated with hypertension and suppression of plasma renin activity, the causes of which are unclear. To determine whether suppressed plasma renin activity is due to extracellular fluid volume expansion, 10 cyclosporine-treated renal transplant recipients were compared with 10 azathioprine-treated renal transplant recipients
Thomas F. Ferris +2 more
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