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Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS).
Inna P. Gladysheva+3 more
doaj +1 more source
Measurement of renin in both renal veins: its use in diagnosis of renovascular hypertension [PDF]
THE RECENT development of a simple reliable method for measuring plasma renin activity, together with the availability of a safe procedure for obtaining samples of blood from both renal veins, has prompted us to assess the utility of such measurements in
Foster, John H.+5 more
core +1 more source
Background: Plasma renin activity is involved in the regulation of body salt content and blood pressure. However, there is a paucity of data regarding the association between low or high plasma renin activity and the development of hypertension.
Eun Ho Choo+6 more
doaj +1 more source
Objective To compare the sensitivity and specificity of chemiluminescence immunoassay (CLIA) and radioimmunoassay (RIA) in detection of aldosterone and renin, and to explore the optional detection methods and indicators for screening primary ...
HONG Yangning+3 more
doaj +1 more source
Plasma Renin Activity in Pheochromocytoma
Plasma renin activity was measured in seven patients with pheochromocytoma. Increased plasma renin activity was consistently observed in five cases, in whom urinary excretion of noradrenaline was higher than that of adrenaline. In one patient, there occurred a progressive rise in plasma renin activity with a proportionate increase in urinary excretion ...
Yukio Miura+3 more
openaire +4 more sources
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G+15 more
core +2 more sources
Background Reninoma is a rare, benign renal neoplasm. Typical clinical features include severe hypertension, secondary hyperaldosteronism, hypokalaemia and metabolic alkalosis caused by the overproduction of renin.
Baoping Wang+12 more
doaj +1 more source
Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of ACE2/AT2R/Mas [PDF]
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze+10 more
core +1 more source
Mechanisms of hypertension during and after orthotopic liver transplantation in children [PDF]
The aim of this study was to assess the hormonal alterations that may mediate the systemic hypertension that develops in patients during the perioperative period of orthotopic liver transplantation.
Akerstedt+72 more
core +1 more source
Immunoradiometric Assay of Active Renin in Human Plasma: Comparison with Plasma Renin Activity
The direct measurement of active renin with monoclonal antibodies (IRMA) in plasma from hypertensive patients was compared with the traditional PRA method. Two monoclonal antibodies were used: 3E8 and 4G1. The first was coupled to magnetizable beads and was used to trap both active and inactive renin from plasma. The second antibody, 4G1, was iodinated
Paolo Madeddu+5 more
openaire +3 more sources