Results 41 to 50 of about 93,450 (318)

Plasma renin activity following renal transplantation [PDF]

Postgraduate Medical Journal, 1978
Summary Plasma renin activity (PRA) was studied serially for up to 21 days following transplantation in thirteen patients receiving renal allografts. PRA was measured during fasting and recumvency and its relationship to renal function, diuretic administration, plasma sodium, allograft rejection and blood pressure was examined.
M H, Snow, S J, Jachuck, V, Robson, R, Wilkinson   +3 more
openaire   +2 more sources

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Effect of Breed on Plasma Endothelin‐1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs

Journal of Veterinary Internal Medicine, 2016
Background There are breed differences in several blood variables in healthy dogs. Objective Investigate breed variation in plasma endothelin‐1 (ET‐1) concentration, plasma renin activity, and serum cortisol concentration. Animals Five‐hundred and thirty‐
K. Höglund, A.‐S. Lequarré, I. Ljungvall, K. Mc Entee, A.‐C. Merveille, M. Wiberg, V. Gouni, J. Lundgren Willesen, S. Hanås, G. Wess, L. Mejer Sørensen, L. Tiret, M. Kierczak, S.K.G. Forsberg, E. Seppälä, K. Lindblad‐Toh, H. Lohi, V. Chetboul, M. Fredholm, J. Häggström   +19 more
doaj   +1 more source

Renin-Angiotensin-Aldosterone System, Glucose Metabolism and Incident Type 2 Diabetes Mellitus: MESA. [PDF]

, 2018
Background Mechanistic studies suggest that aldosterone impairs glucose metabolism. We investigated the cross-sectional associations of aldosterone and plasma renin activity with fasting plasma glucose, insulin resistance ( IR ), β-cell function, and ...
Allison, Matthew A, Echouffo Tcheugui, Justin B, Effoe, Valery S, Golden, Sherita H, Hsueh, Willa A, Joseph, Joshua J   +5 more
core   +1 more source

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.

PLoS ONE, 2022
BackgroundSickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure (BP), via an ...
Pamela L Brito, Alisson F Dos Santos, Hanan Chweih, Maria E Favero, Erica M F Gotardo, Juliete A F Silva, Flavia C Leonardo, Carla F Franco-Penteado, Mariana G de Oliveira, Wilson A Ferreira, Bruna C Zaidan, Athanase Billis, Giorgio Baldanzi, Denise A Mashima, Edson Antunes, Sara T Olalla Saad, Fernando F Costa, Nicola Conran   +17 more
doaj   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Recovery from Hepatorenal Syndrome after Orthotopic Liver Transplantation [PDF]

, 1973
Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation.
Berk, Berkowitz, Berkowitz, Charles W. Putnam, Fred H. Katz, Jacques L. Corman, Makoto Ishikawa, Mordecai M. Popovtzer, Shunzaburo Iwatsuki, Thomas E. Starzl   +9 more
core   +1 more source

PLASMA RENIN ACTIVITY IN RENOVASCULAR HYPERTENSION

Japanese Circulation Journal, 1971
Dynamics of plasma renin activity (PRA) in peripheral and renal vein was studied in 22 patients with various types of renovascular hypertension. Significant elevation of resting peripheral vein PRA (PPRA) was observed in 7 out of 8 cases with unilateral main renal artery stenosis (type I).
YUKIO MIURA, TATSUO SATO, KEISHI ABE, ISAO MIWA, IWAO ONO, KAORU YOSHINAGA   +5 more
openaire   +3 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source