Results 181 to 190 of about 106,539 (308)

An Absolute Quantitative Approach to Study the Desorption Step in Plasma-Based Ambient MS Methods. [PDF]

Anal Chem
Gazeli O, Moreno-González D, Bouza M, Anastassiou C, Georghiou GE, Molina-Diaz A, Franzke J, García-Reyes JF.   +7 more
europepmc   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Development and preclinical results of a transcatheter aortic valve implant with novel polymeric leaflets. [PDF]

NPJ Cardiovasc Health
Stanfield JR, Johnson G, Belais N, George I, Yakubov S.   +4 more
europepmc   +1 more source

Synergistic Blend Spinning of Bioactive Lyocell Fibers for Antibacterial and Anti‐Inflammatory Skin Protection

Macromolecular Materials and Engineering, Volume 311, Issue 4, April 2026.
Multifunctional lyocell fibers are engineered by synergistic blend spinning of bioactive small molecules and zinc ions. The fibers exhibit durable antibacterial activity, suppress infection‐induced inflammation, modulate macrophage polarization, and promote angiogenesis and collagen remodeling, thereby accelerating healing of bacteria‐infected wounds ...
Xiongwei Dong, Kaixin Ran, Yujie Wang, Zixiong Yin, Zewei Zheng, Cheng Gao, Yi Xiong, Yun Tang, Sakil Mahmud   +8 more
wiley   +1 more source

Advancements and Challenges in Tissue-Engineered Heart Valves: Integrating Biomechanics, Biomaterials, and Biomimetic Design for Functional Maturity. [PDF]

Biomimetics (Basel)
Guidi L, Rosellini E, Riccio G, Cascone MG.   +3 more
europepmc   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Gas Plasma Combination Therapies-Promises from Preclinical Oncology Research. [PDF]

Antioxidants (Basel)
Yu L, Berner J, Martinet A, Freund E, Singer D, von Woedtke T, Weltmann KD, Emmert S, Clemen R, Bekeschus S.   +9 more
europepmc   +1 more source

The Application of Metal–Organic Frameworks as Drug Delivery Systems: From the Perspective of Molecular Dynamics Simulations

MedComm, Volume 7, Issue 4, April 2026.
This review article provides a comprehensive exploration of the synergistic integration of molecular dynamics (MD) simulations and metal–organic frameworks (MOFs) to advance the design and optimization of nanoscale drug delivery systems (DDSs). We believe this work will be of significant interest to researchers in nanomedicine, computational biology ...
Jiahao Xu, Hanzi Zheng, Yue Gao, Yuanqiu Lai, Mengya Peng, Yike Hu, Tianmeng Yuan, Xiang Liu, Shihan Zhou, Wei Duan, Jia‐Wei Shen, Yongke Zheng   +11 more
wiley   +1 more source

Electrospun 3D Nanofiber Scaffolds with Adhesion-Enhanced Interfaces for Cell Culture. [PDF]

ACS Omega
Moon SH, Jo JH, Park SJ, Jeon HR, Yang YJ.   +4 more
europepmc   +1 more source