Results 41 to 50 of about 1,688,902 (296)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Chemical freezeout in relativistic A+A collisions: is it close to the QGP? [PDF]

, 2005
Preliminary experimental data for particle number ratios in the collisions of Au+Au at the BNL AGS (11A GeV/c) and Pb+Pb at the CERN SPS (160A GeV/c) are analyzed in a thermodynamically consistent hadron gas model with excluded volume.
Gorenstein, Mark I., Greiner, Walter, Stöcker, Horst, Yang, Shin Nan, Yen, Granddon D.   +4 more
core  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

The Unexpected Role of Evolving Longitudinal Electric Fields in Generating Energetic Electrons in Relativistically Transparent Plasmas

, 2018
Superponderomotive-energy electrons are observed experimentally from the interaction of an intense laser pulse with a relativistically transparent target.
Arefiev, A. V., Chen, H., Dollar, F., Hazi, A. U., Maksimchuk, A., Manuel, M. J. -E., Marley, E., Nazarov, W., Williams, G. J., Willingale, L., Zhao, T. Z., Zulick, C.   +11 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

ESTIMATED PLASMA VOLUME AS A TOOL IN PREDICTING OUTCOMES AMONG HEART TRANSPLANT PATIENTS [PDF]

, 2023
S. Jonna, Shahin Isha, PARTHKUMAR SATASHIA, Humera Batool, Anna Jenkins, Abby Hanson, Prasanth Balasubramanian, Ricardo Diaz Milian, NEAL M PATEL, SANJAY CHAUDHARY, Anirban Bhattacharyya, PRAMOD K GURU, Parag C. Patel, Pablo Moreno Franco, DEVANG SANGHAVI   +14 more
openalex   +1 more source

Macroscopic phase segregation in superconducting K0.73Fe1.67Se2 as seen by muon spin rotation and infrared spectroscopy

, 2012
Using muon spin rotation (\muSR) and infrared spectroscopy we investigated the recently discovered superconductor K0.73Fe1.67Se2 with Tc = 32 K. We show that the combined data can be consistently described in terms of a macroscopically phase segregated ...
A. Dubroka, A. F. Wang, A. Schenck, A. Sihvola, C. Bernhard, C. N. Wang, Ch. Niedermayer, D. X. Mou, G. D. Varma, M. Rössle, P. Marsik, R. Schuster, T. Wolf, X. H. Chen   +13 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source