Results 71 to 80 of about 143,775 (300)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Solar Orbiter encounters an unusually high Mach number interplanetary shock

Astronomy & Astrophysics
Aims. The objective of this study is to characterise and understand the magnetic structure of an extremely high Mach number interplanetary shock. Methods.
Dimmock A. P., Boldú J. J., Trotta D., Lalti A., Graham D. B., Lindberg M., Hietala H., Khotyaintsev Yu. V.   +7 more
doaj   +1 more source

Statistical Analysis of Langmuir Waves Associated with Type III Radio Bursts: II. Simulation and Interpretation of the Wave Energy Distributions

Open Astronomy, 2011
We have modeled electrostatic Langmuir waves by an electric field, consisting of superposition of Gaussian wave packets with several probability distributions of amplitudes and with several Poisson distributions of wave packets.
Maksimović M., Vidojević S., Zaslavsky A.   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A complete X-ray view of supernova remnant W28 with the Einstein Probe: Spatial distribution of parameters, and the origin of the thermal-composite morphology

Astronomy & Astrophysics
The question about what causes a supernova remnant (SNR) to be a thermal composite rather than have a typical shell-like morphology remains unsolved, as does what causes the plasma inside it to recombine.
Chi Yi-Heng, Zhou Ping, Chen Yang, Sun Lei, Li Chengkui, Jia Shumei, Chen Yong, Ge Chong, Yuan Weimin   +8 more
doaj   +1 more source

Plasma kinetics in molecular plasmas and modeling of reentry plasmas

Plasma Physics and Controlled Fusion, 2011
State-to-state non-equilibrium plasma kinetics is widely used to characterize cold molecular and reentry plasmas. The approach requires a high level of dynamical information, and demands a large effort in the creation of complete databases of state-resolved cross sections and rate coefficients.
M Capitelli, R Celiberto, GColonna, GD'Ammando, ODe Pascale, P Diomede, F Esposito, CGorse, A Laricchiuta, S Longo, LD Pietanza, FTaccogna   +11 more
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A robust super-time-stepping scheme for Ohmic and ambipolar diffusion

Astronomy & Astrophysics
Context. Nonideal magnetohydrodynamics (MHD) is a key tool for modeling magnetic flux transport in astrophysical systems such as molecular clouds, protostellar cores, and protoplanetary disks.
Mattia G., Flock M., Melon Fuksman D., Tzouvanou A., Berta V., Crocco D.   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Probing anisotropic particle acceleration and limb brightening in Centaurus A’s jet

Astronomy & Astrophysics
Context. Relativistic jets are among the most fascinating phenomena in the universe, and recent high-resolution very long baseline interferometric (VLBI) observations, including the Global mm-VLBI Array and the Event Horizon Telescope (EHT), are able to ...
Glaser Felix, Fromm Christian. M., Ricci Luca, Mizuno Yosuke, Kadler Matthias, Mannheim Karl, Janssen Michael   +6 more
doaj   +1 more source