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Plasmid-mediated quinolone resistance: an update
Journal of Infection and Chemotherapy, 2011In 1998, the first plasmid-mediated gene involved in quinolone resistance (currently named qnrA1) was reported. Extra qnr-like plasmid-mediated genes (qnrB, qnrS, qnrC, qnrD) and their chromosomal homologues have also been characterized. These genes code for a pentapeptide repeat protein that protects type II topoisomerases from quinolones. Since then,
J M Rodríguez-Martínez +2 more
exaly +3 more sources
Plasmid-mediated quinolone resistance: Two decades on
Drug Resistance Updates, 2016After two decades of the discovery of plasmid-mediated quinolone resistance (PMQR), three different mechanisms have been associated to this phenomenon: target protection (Qnr proteins, including several families with multiple alleles), active efflux pumps (mainly QepA and OqxAB pumps) and drug modification [AAC(6')-Ib-cr acetyltransferase].
J M Rodríguez-Martínez +2 more
exaly +3 more sources
The worldwide emergence of plasmid-mediated quinolone resistance
The Lancet Infectious Diseases, 2006Fluoroquinolone resistance is emerging in gram-negative pathogens worldwide. The traditional understanding that quinolone resistance is acquired only through mutation and transmitted only vertically does not entirely account for the relative ease with which resistance develops in exquisitely susceptible organisms, or for the very strong association ...
Ari, Robicsek +2 more
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Plasmid-mediated quinolone resistance – current knowledge and future perspectives [PDF]
Journal of International Medical Research, 2013 Quinolones are a group of antimicrobial agents that were serendipitously discovered as byproducts of the synthesis of chloroquine. Chemical modifications, such as the addition of fluorine or piperazine, resulted in the synthesis of third- and fourth-generation fluoroquinolones, with broad-spectrum antimicrobial actions against aerobic or anaerobic ...
Xizhou, Guan +11 more
exaly +3 more sources
Plasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries
Infection, Genetics and Evolution, 2019 Quinolones are an important antimicrobial class used widely in the treatment of enterobacterial infections. Although there are multiple mechanisms of quinolone resistance, attention should be paid to plasmid-mediated genes due to their ability to facilitate the spread of quinolone resistance, the selection of mutants with a higher-level of quinolone ...
Iman Yassine +2 more
exaly +3 more sources
[Mechanisms of plasmid-mediated resistance to quinolones].
Enfermedades infecciosas y microbiologia clinica, 2005Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmid-mediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid.
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Quinolone resistance in bacteria: emphasis on plasmid-mediated mechanisms
International Journal of Antimicrobial Agents, 2005Bacterial resistance to quinolones/fluoroquinolones has emerged rapidly and such resistance has traditionally been attributed to the chromosomally mediated mechanisms that alter the quinolone targets (i.e. DNA gyrase and topoisomerase IV) and/or overproduce multidrug resistance efflux pumps.
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Study of Plasmid-Mediated Quinolone Resistance in Bacteria
2017Plasmid-mediated quinolone resistance (PMQR) involves genes for proteins that protect the quinolone targets, an enzyme that inactivates certain quinolones as well as aminoglycosides, and pumps that efflux quinolones. Quinolone susceptibility is reduced by these mechanisms but not to the level of clinical resistance unless chromosomal mutations are also
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Plasmid-Mediated Quinolone Resistance in Gram-Negative Bacterial Species: An Update
Current Medicinal Chemistry, 2009Resistance to quinolones and fluoroquinolones has been increasingly reported among human and veterinary isolates during the last three decades related to their wide clinical use. Until recently, the mechanisms of resistance to quinolones in Enterobacteriaceae were believed to be only chromosome-encoded, i.e.
Vincent, Cattoir, Patrice, Nordmann
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2021
Fluoroquinolones, are effective agents both against gram-positive and gram-negative bacteria. Quinolones show bactericidal effect as a result of inhibition of DNA gyrase and topoisomerase IV enzymes. Main quinolo resistance mechanisms are chromosomal mutations in these enzymes and decreased intracellular accumulation due to efflux pumps or decreased ...
TANRIVERDİ ÇAYCI, Yeliz +2 more
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Fluoroquinolones, are effective agents both against gram-positive and gram-negative bacteria. Quinolones show bactericidal effect as a result of inhibition of DNA gyrase and topoisomerase IV enzymes. Main quinolo resistance mechanisms are chromosomal mutations in these enzymes and decreased intracellular accumulation due to efflux pumps or decreased ...
TANRIVERDİ ÇAYCI, Yeliz +2 more
openaire +2 more sources